Bovine Tau antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-Tau-Ag01	Recombinant Bovine Tau protein	3090
GMP-BOV-Tau-Ab01	Anti-Bovine Tau mouse monoclonal antibody (mAb)	1953
GMP-BOV-Tau-Ab02	Anti-Bovine Tau mouse monoclonal antibody (mAb)	1953
GMP-BOV-Tau-Ab03	Anti-Bovine Tau human monoclonal antibody (mAb)	1953
GMP-BOV-Tau-Ab04	Anti-Bovine Tau human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-Tau-Ag01
Product Name	Recombinant Bovine Tau protein
Target/Biomarker	Bovine tau proteins (RLN)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine tau proteins antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in RLN level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Bovine Tau protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Tau-Ab01, GMP-BOV-Tau-Ab02
Product Name	Anti-Bovine Tau mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine tau proteins (RLN)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine tau proteins antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies in RLN level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Bovine Tau mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Tau-Ab03, GMP-BOV-Tau-Ab04
Product Name	Anti-Bovine Tau human monoclonal antibody (mAb)
Target/Biomarker	Bovine tau proteins (RLN)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine tau proteins antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies in RLN level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Bovine Tau human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-RLN antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Bovine Tau stands as a sentinel in the intricate landscape of cattle neurobiology. This protein, primarily localized within the central nervous system (CNS) of cattle, serves as a guardian of neuronal structural integrity and function. Its structural and functional homology to tau proteins in other species, including humans, underscores its critical role in maintaining proper neurological health. Structurally, Bovine Tau belongs to the tau protein family, sharing genetic and functional commonalities with its counterparts in diverse organisms. Its primary function is to bind to microtubules within neurons, promoting their assembly and stability. Microtubules are essential cellular structures that facilitate axonal transport, synaptic plasticity, and overall neuronal communication. However, the equilibrium of tau proteins like Bovine Tau can be disrupted in the context of neurodegenerative conditions observed in cattle. Tau proteins may undergo post-translational modifications, including hyperphosphorylation. These modifications lead to tau proteins adopting atypical conformations, rendering them susceptible to aggregation. The aggregation of tau proteins culminates in the formation of neurofibrillary tangles within neurons. These tangles impede axonal transport, compromise synaptic function, and eventually result in neuronal dysfunction and degeneration. The presence of elevated levels of Bovine Tau in specific contexts can serve as an indicator of these pathological processes, signaling the potential emergence of cognitive and neurological deficits in affected cattle.

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