Bovine SAHH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-SAHH-Ag01	Recombinant Bovine SAHH protein	3090
GMP-BOV-SAHH-Ab01	Anti-Bovine SAHH mouse monoclonal antibody (mAb)	1953
GMP-BOV-SAHH-Ab02	Anti-Bovine SAHH mouse monoclonal antibody (mAb)	1953
GMP-BOV-SAHH-Ab03	Anti-Bovine SAHH human monoclonal antibody (mAb)	1953
GMP-BOV-SAHH-Ab04	Anti-Bovine SAHH human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-BOV-SAHH-Ag01
Product Name	Recombinant Bovine SAHH protein
Target/Biomarker	Bovine S-adenosylhomocysteine (SAHH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine S-adenosylhomocysteine antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in SAHH level test of animal Bovines/Cattle with S-adenosylhomocysteine (AdoHcy) hydrolase deficiency.
Tag	His
Products description	Recombinant Bovine SAHH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-SAHH-Ab01, GMP-BOV-SAHH-Ab02
Product Name	Anti-Bovine SAHH mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine S-adenosylhomocysteine (SAHH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine S-adenosylhomocysteine antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAHH antibodies in SAHH level test of animal Bovines/Cattle with S-adenosylhomocysteine (AdoHcy) hydrolase deficiency.
Tag	mFc
Products description	Anti-Bovine SAHH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAHH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-SAHH-Ab03, GMP-BOV-SAHH-Ab04
Product Name	Anti-Bovine SAHH human monoclonal antibody (mAb)
Target/Biomarker	Bovine S-adenosylhomocysteine (SAHH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine S-adenosylhomocysteine antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAHH antibodies in SAHH level test of animal Bovines/Cattle with S-adenosylhomocysteine (AdoHcy) hydrolase deficiency.
Tag	hFc
Products description	Anti-Bovine SAHH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-SAHH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

S-Adenosylhomocysteine Hydrolase (SAHH) within the bovine (cattle) population embodies the intricate dance of biochemistry within these robust creatures. At its core, SAHH serves as a linchpin in the methylation cycle, a fundamental metabolic pathway essential for bovine health. Structurally, SAHH is an enzyme with a pivotal role – the hydrolysis of S-Adenosylhomocysteine (SAH). SAH is a metabolic byproduct arising from methylation reactions, a process involved in the transfer of methyl groups to DNA, RNA, proteins, and other molecules. When SAH accumulates, it inhibits the activity of methyltransferase enzymes, which are responsible for DNA and RNA methylation, protein modifications, and the synthesis of neurotransmitters. SAHH acts as the enzyme that quells the potential chaos caused by excessive SAH. It cleaves SAH into adenosine and homocysteine, effectively preventing the buildup of SAH to inhibitory levels. This regulatory role is paramount, as it ensures that the methylation cycle continues to function harmoniously. SAHH's significance goes beyond its enzymatic function; it extends to the broader spectrum of bovine biology. Methylation reactions are intricately tied to gene expression and regulation. When SAHH and the methylation cycle operate optimally, genes are appropriately activated or silenced, influencing the bovine phenotype, physiology, and overall health.

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