Bovine Proinsulin antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-Proinsulin-Ag01	Recombinant Bovine Proinsulin protein	3090
GMP-BOV-Proinsulin-Ab01	Anti-Bovine Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-BOV-Proinsulin-Ab02	Anti-Bovine Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-BOV-Proinsulin-Ab03	Anti-Bovine Proinsulin human monoclonal antibody (mAb)	1953
GMP-BOV-Proinsulin-Ab04	Anti-Bovine Proinsulin human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-Proinsulin-Ag01
Product Name	Recombinant Bovine Proinsulin protein
Target/Biomarker	Bovine Proinsulin ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Proinsulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Bovines/Cattle with type 2 diabetes.
Tag	His
Products description	Recombinant Bovine Proinsulin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Proinsulin-Ab01, GMP-BOV-Proinsulin-Ab02
Product Name	Anti-Bovine Proinsulin mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine Proinsulin ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Bovines/Cattle with type 2 diabetes.
Tag	mFc
Products description	Anti-Bovine Proinsulin mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Proinsulin-Ab03, GMP-BOV-Proinsulin-Ab04
Product Name	Anti-Bovine Proinsulin human monoclonal antibody (mAb)
Target/Biomarker	Bovine Proinsulin ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Bovines/Cattle with type 2 diabetes.
Tag	hFc
Products description	Anti-Bovine Proinsulin human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Bovine Proinsulin, an intricate 86-amino acid peptide hormone, occupies a pivotal position in the complex orchestra of insulin biosynthesis within cattle. It is synthesized and secreted by the beta cells nestled within the pancreatic islets of Langerhans, marking the initiation of insulin production. The journey of Cattle Proinsulin begins with the synthesis of preproinsulin, a larger precursor molecule. This preproinsulin subsequently undergoes a profound transformation, folding into proinsulin, a molecule comprising three distinct regions: the A chain, B chain, and a connecting peptide known as the C-peptide. The C-peptide, an integral component of proinsulin, is significant for its role in insulin biosynthesis. During proinsulin processing, a series of specific enzymes operate with precision to cleave the C-peptide from proinsulin. This cleavage event marks a critical transition, as it transforms proinsulin into the active insulin molecule. The newly formed insulin is then released into circulation, where it exerts its profound influence on glucose metabolism. The presence of the C-peptide within proinsulin is more than a structural element; it holds physiological significance. While it does not possess the same glucose-lowering properties as insulin, research suggests that the C-peptide may have independent actions on blood vessel health and other metabolic processes, making it a subject of scientific interest and exploration.

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