Bovine PTH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-PTH-Ag01	Recombinant Bovine PTH protein	3090
GMP-BOV-PTH-Ab01	Anti-Bovine PTH mouse monoclonal antibody (mAb)	1953
GMP-BOV-PTH-Ab02	Anti-Bovine PTH mouse monoclonal antibody (mAb)	1953
GMP-BOV-PTH-Ab03	Anti-Bovine PTH human monoclonal antibody (mAb)	1953
GMP-BOV-PTH-Ab04	Anti-Bovine PTH human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-PTH-Ag01
Product Name	Recombinant Bovine PTH protein
Target/Biomarker	Bovine parathyroid hormone (PTH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine parathyroid hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PTH level test of animal Bovines/Cattle with Hyperparathyroidism.
Tag	His
Products description	Recombinant Bovine PTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-PTH-Ab01, GMP-BOV-PTH-Ab02
Product Name	Anti-Bovine PTH mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine parathyroid hormone (PTH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine parathyroid hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies in PTH level test of animal Bovines/Cattle with Hyperparathyroidism.
Tag	mFc
Products description	Anti-Bovine PTH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-PTH-Ab03, GMP-BOV-PTH-Ab04
Product Name	Anti-Bovine PTH human monoclonal antibody (mAb)
Target/Biomarker	Bovine parathyroid hormone (PTH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine parathyroid hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies in PTH level test of animal Bovines/Cattle with Hyperparathyroidism.
Tag	hFc
Products description	Anti-Bovine PTH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Parathyroid Hormone (PTH) in cattle, often referred to as bovines, stands as a remarkable biomarker central to the intricate dance of calcium and phosphorus regulation within these ruminant animals. Structurally, PTH consists of 84 amino acids and is synthesized predominantly in the parathyroid glands, four small, pea-sized structures nestled adjacent to the thyroid gland. The fundamental role of PTH is the maintenance of calcium and phosphorus homeostasis. In response to fluctuations in serum calcium levels, PTH secretion is tightly regulated. When calcium levels plummet, PTH is swiftly released into the bloodstream, setting in motion a cascade of physiological responses designed to restore calcium balance. One of PTH's primary actions in cattle is its stimulation of osteoclast activity. Osteoclasts are specialized bone cells responsible for resorbing bone tissue. When PTH binds to its receptors on osteoclasts, it signals these cells to break down bone matrix, releasing calcium and phosphorus into the bloodstream. This process, known as bone resorption, provides a rapid source of these minerals to meet immediate physiological demands. Beyond bone resorption, PTH exerts its influence on renal function. It enhances the reabsorption of calcium in the renal tubules, reducing calcium loss through urine. This conserves calcium within the body. Moreover, PTH indirectly promotes calcium and phosphorus absorption from the gastrointestinal tract by stimulating the synthesis of calcitriol, the active form of vitamin D. Calcitriol, in turn, enhances the efficiency of calcium and phosphorus absorption in the intestines, ensuring a comprehensive approach to mineral balance. PTH's significance in cattle physiology extends beyond mineral homeostasis. Adequate calcium levels are indispensable for muscle function and nerve transmission. A deficiency in calcium can lead to neuromuscular issues, affecting the ability of cattle to stand, walk, or even perform routine bodily functions. Therefore, PTH plays a pivotal role in maintaining not only skeletal health but also the overall physiological stability of bovines.

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