Bovine Ins antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-Ins-Ag01	Recombinant Bovine Ins protein	3090
GMP-BOV-Ins-Ab01	Anti-Bovine Ins mouse monoclonal antibody (mAb)	1953
GMP-BOV-Ins-Ab02	Anti-Bovine Ins mouse monoclonal antibody (mAb)	1953
GMP-BOV-Ins-Ab03	Anti-Bovine Ins human monoclonal antibody (mAb)	1953
GMP-BOV-Ins-Ab04	Anti-Bovine Ins human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-Ins-Ag01
Product Name	Recombinant Bovine Ins protein
Target/Biomarker	Bovine Insulin (Ins)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Insulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Ins level test of animal Bovines/Cattle with Diabetes mellitus.
Tag	His
Products description	Recombinant Bovine Ins protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Ins-Ab01, GMP-BOV-Ins-Ab02
Product Name	Anti-Bovine Ins mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine Insulin (Ins)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Bovines/Cattle with Diabetes mellitus.
Tag	mFc
Products description	Anti-Bovine Ins mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Ins-Ab03, GMP-BOV-Ins-Ab04
Product Name	Anti-Bovine Ins human monoclonal antibody (mAb)
Target/Biomarker	Bovine Insulin (Ins)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine Insulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies in Ins level test of animal Bovines/Cattle with Diabetes mellitus.
Tag	hFc
Products description	Anti-Bovine Ins human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Ins antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Bovine Insulin, an intricate peptide hormone consisting of 51 amino acids, reigns as a central player in the symphony of glucose regulation within cattle. Produced and secreted by the beta cells nestled within the pancreatic islets of Langerhans, it serves as a conductor, directing cellular glucose uptake and utilization in these magnificent creatures. At its core, Bovine Insulin is tasked with the facilitation of cellular glucose uptake. Once released into circulation, it embarks on a mission, seeking out insulin receptors on the surfaces of target cells, particularly those in skeletal muscle and adipose tissue. The binding of Bovine Insulin to these receptors sets off a meticulously orchestrated cascade of intracellular signaling events. This cascade culminates in the translocation of glucose transporters (GLUT4) to the cell membrane. These transporters act as guardians, permitting the entry of glucose into the cell, where it can be either metabolized for immediate energy production through glycolysis or stored as glycogen for future energy needs. The secretion of Bovine Insulin is intricately entwined with blood glucose levels. After a hearty meal, as blood glucose levels surge, the beta cells within cattle's pancreas respond by releasing insulin into circulation. This insulin surge drives glucose uptake into cells, leading to a reduction in blood glucose levels and the restoration of metabolic equilibrium. In contrast, during fasting or periods of heightened energy demand, Bovine Insulin secretion wanes, allowing the release of stored glucose to maintain essential glucose homeostasis.

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