Haptoglobin antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-Haptoglobin-Ag01	Recombinant Haptoglobin protein	3090
GMP-BOV-Haptoglobin-Ab01	Anti-Haptoglobin mouse monoclonal antibody (mAb)	1953
GMP-BOV-Haptoglobin-Ab02	Anti-Haptoglobin mouse monoclonal antibody (mAb)	1953
GMP-BOV-Haptoglobin-Ab03	Anti-Haptoglobin human monoclonal antibody (mAb)	1953
GMP-BOV-Haptoglobin-Ab04	Anti-Haptoglobin human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-BOV-Haptoglobin-Ag01
Product Name	Recombinant Haptoglobin protein
Target/Biomarker	Bovine Haptoglobin (HP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Haptoglobin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in HP level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	His
Products description	Recombinant Haptoglobin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Haptoglobin-Ab01, GMP-BOV-Haptoglobin-Ab02
Product Name	Anti-Haptoglobin mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine Haptoglobin (HP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies in HP level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	mFc
Products description	Anti-Haptoglobin mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-Haptoglobin-Ab03, GMP-BOV-Haptoglobin-Ab04
Product Name	Anti-Haptoglobin human monoclonal antibody (mAb)
Target/Biomarker	Bovine Haptoglobin (HP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine Haptoglobin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies in HP level test of animal Bovines/Cattle with milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis.
Tag	hFc
Products description	Anti-Haptoglobin human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Bovine Haptoglobin, an indispensable component of the bovine immune system, stands as a sentinel of inflammation and infection within the cattle body. Structurally, it is a glycoprotein synthesized primarily in the hepatocytes of the liver, spurred into production by the clarion call of pro-inflammatory cytokines, particularly interleukin-6 (IL-6). The central function of Bovine Haptoglobin revolves around its remarkable ability to bind free hemoglobin molecules. When red blood cells succumb to damage or lysis, hemoglobin is released into the bloodstream, where it could potentially wreak havoc. Free hemoglobin, in its unbridled state, can induce oxidative damage and may precipitate kidney filtration, leading to renal damage. Haptoglobin, ever vigilant, steps in to avert this crisis. It swiftly forms stable complexes with free hemoglobin, rendering it inert and facilitating its clearance by the reticuloendothelial system. The significance of this hemoglobin-binding function cannot be overstated. By sequestering free hemoglobin, Haptoglobin serves as a guardian against the adverse consequences of hemolysis, preserving the integrity of the bovine circulatory system and minimizing the risk of oxidative damage. Beyond its hemoglobin-binding role, Haptoglobin exhibits intriguing immunomodulatory properties. It possesses the capability to interact with immune cells, contributing to the modulation of the inflammatory response. In this capacity, Haptoglobin assumes the role of an immunological maestro, orchestrating the actions of immune cells to address specific threats. This immunomodulation may involve the regulation of cytokine production, influencing the recruitment of immune cells to the site of infection, or modulating the phagocytic activity of macrophages.

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