Bovine Aβ42 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-BOV-AB42-Ag01	Recombinant Bovine Aβ42 protein	3090
GMP-BOV-AB42-Ab01	Anti-Bovine Aβ42 mouse monoclonal antibody (mAb)	1953
GMP-BOV-AB42-Ab02	Anti-Bovine Aβ42 mouse monoclonal antibody (mAb)	1953
GMP-BOV-AB42-Ab03	Anti-Bovine Aβ42 human monoclonal antibody (mAb)	1953
GMP-BOV-AB42-Ab04	Anti-Bovine Aβ42 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-BOV-AB42-Ag01
Product Name	Recombinant Bovine Aβ42 protein
Target/Biomarker	Bovine beta-amyloid 42 ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine beta-amyloid 42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Bovine Aβ42 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-AB42-Ab01, GMP-BOV-AB42-Ab02
Product Name	Anti-Bovine Aβ42 mouse monoclonal antibody (mAb)
Target/Biomarker	Bovine beta-amyloid 42 ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine beta-amyloid 42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Bovine Aβ42 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-BOV-AB42-Ab03, GMP-BOV-AB42-Ab04
Product Name	Anti-Bovine Aβ42 human monoclonal antibody (mAb)
Target/Biomarker	Bovine beta-amyloid 42 ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Bovine beta-amyloid 42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Bovine Aβ42 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Bovine Amyloid-beta 42 (Aβ42) is a remarkable molecule in bovine neuropathology, occupying a central role in our understanding of neurodegenerative conditions afflicting cattle. Comprising 42 amino acids, Aβ42 is a fragment of the amyloid precursor protein (APP) and serves as a critical component in the formation of amyloid plaques within the bovine brain. These plaques, primarily composed of Aβ42, are emblematic pathological features associated with cognitive dysfunction in cattle, most notably in cases of bovine spongiform encephalopathy (BSE), colloquially referred to as "mad cow disease." The generation of Aβ42 occurs through the proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In cattle afflicted by BSE, an aberration in Aβ42 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neural function, contributing significantly to cognitive deficits, neural degeneration, and the clinical manifestations observed in affected cattle. The implications of Aβ42 aggregation extend further, encompassing a cascade of pathological events. These include neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively exacerbate the neurodegenerative processes occurring in cattle suffering from BSE.

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