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Anti-I17RC/ IL17RC/ CANDF9 monoclonal antibody
Anti-I17RC/ IL17RC/ CANDF9 antibody for FACS & in-vivo assay
Go to IL17RC/IL17RC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA144-Ab-1/ GM-Tg-hg-TA144-Ab-2 | Anti-Human IL17RC monoclonal antibody | Human |
| GM-Tg-rg-TA144-Ab-1/ GM-Tg-rg-TA144-Ab-2 | Anti-Rat IL17RC monoclonal antibody | Rat |
| GM-Tg-mg-TA144-Ab-1/ GM-Tg-mg-TA144-Ab-2 | Anti-Mouse IL17RC monoclonal antibody | Mouse |
| GM-Tg-cynog-TA144-Ab-1/ GM-Tg-cynog-TA144-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL17RC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA144-Ab-1/ GM-Tg-felg-TA144-Ab-2 | Anti-Feline IL17RC monoclonal antibody | Feline |
| GM-Tg-cang-TA144-Ab-1/ GM-Tg-cang-TA144-Ab-2 | Anti-Canine IL17RC monoclonal antibody | Canine |
| GM-Tg-bovg-TA144-Ab-1/ GM-Tg-bovg-TA144-Ab-2 | Anti-Bovine IL17RC monoclonal antibody | Bovine |
| GM-Tg-equg-TA144-Ab-1/ GM-Tg-equg-TA144-Ab-2 | Anti-Equine IL17RC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA144-Ab-1/ GM-Tg-hg-TA144-Ab-2; GM-Tg-rg-TA144-Ab-1/ GM-Tg-rg-TA144-Ab-2; GM-Tg-mg-TA144-Ab-1/ GM-Tg-mg-TA144-Ab-2; GM-Tg-cynog-TA144-Ab-1/ GM-Tg-cynog-TA144-Ab-2; GM-Tg-felg-TA144-Ab-1/ GM-Tg-felg-TA144-Ab-2; GM-Tg-cang-TA144-Ab-1/ GM-Tg-cang-TA144-Ab-2; GM-Tg-bovg-TA144-Ab-1/ GM-Tg-bovg-TA144-Ab-2; GM-Tg-equg-TA144-Ab-1/ GM-Tg-equg-TA144-Ab-2 |
| Products Name | Anti-IL17RC monoclonal antibody |
| Format | mab |
| Target Name | IL17RC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL17RC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I17RC/ IL17RC/ CANDF9 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-TA144-Ag-1 | interleukin 17 receptor C (IL17RC) protein |
Target information
| Target ID | GM-TA144 |
| Target Name | IL17RC |
| Gene ID | 84818,171095,297520,699223,610118,101092091,504855,100058271 |
| Gene Symbol and Synonyms | 1110025H02Rik,CANDF9,Gm19850,IL-17RC,IL17-RC,IL17-RL,IL17RC,IL17RL |
| Uniprot Accession | Q8NAC3 |
| Uniprot Entry Name | I17RC_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000163702 |
| Target Classification | N/A |
The target: IL17RC, gene name: IL17RC, also named as CANDF9, IL17-RL, IL17RL. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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