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Anti-IL6RB/ IL6ST/ CD130 monoclonal antibody
Anti-IL6RB/ IL6ST/ CD130 antibody for FACS & in-vivo assay
Go to IL6ST/IL6ST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA093-Ab-1/ GM-Tg-hg-TA093-Ab-2 | Anti-Human IL6ST monoclonal antibody | Human |
| GM-Tg-rg-TA093-Ab-1/ GM-Tg-rg-TA093-Ab-2 | Anti-Rat IL6ST monoclonal antibody | Rat |
| GM-Tg-mg-TA093-Ab-1/ GM-Tg-mg-TA093-Ab-2 | Anti-Mouse IL6ST monoclonal antibody | Mouse |
| GM-Tg-cynog-TA093-Ab-1/ GM-Tg-cynog-TA093-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL6ST monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA093-Ab-1/ GM-Tg-felg-TA093-Ab-2 | Anti-Feline IL6ST monoclonal antibody | Feline |
| GM-Tg-cang-TA093-Ab-1/ GM-Tg-cang-TA093-Ab-2 | Anti-Canine IL6ST monoclonal antibody | Canine |
| GM-Tg-bovg-TA093-Ab-1/ GM-Tg-bovg-TA093-Ab-2 | Anti-Bovine IL6ST monoclonal antibody | Bovine |
| GM-Tg-equg-TA093-Ab-1/ GM-Tg-equg-TA093-Ab-2 | Anti-Equine IL6ST monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA093-Ab-1/ GM-Tg-hg-TA093-Ab-2; GM-Tg-rg-TA093-Ab-1/ GM-Tg-rg-TA093-Ab-2; GM-Tg-mg-TA093-Ab-1/ GM-Tg-mg-TA093-Ab-2; GM-Tg-cynog-TA093-Ab-1/ GM-Tg-cynog-TA093-Ab-2; GM-Tg-felg-TA093-Ab-1/ GM-Tg-felg-TA093-Ab-2; GM-Tg-cang-TA093-Ab-1/ GM-Tg-cang-TA093-Ab-2; GM-Tg-bovg-TA093-Ab-1/ GM-Tg-bovg-TA093-Ab-2; GM-Tg-equg-TA093-Ab-1/ GM-Tg-equg-TA093-Ab-2 |
| Products Name | Anti-IL6ST monoclonal antibody |
| Format | mab |
| Target Name | IL6ST |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL6ST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IL6RB/ IL6ST/ CD130 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-TA093-Ag-1 | interleukin 6 signal transducer (IL6ST) protein |
| ORF Viral Vector | pGMLPm004033 | mouse Il6st Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004033 | mouse Il6st Lentivirus particle |
Target information
| Target ID | GM-TA093 |
| Target Name | IL6ST |
| Gene ID | 3572,16195,25205,574127,403545,101089832,522155,100051700 |
| Gene Symbol and Synonyms | 5133400A03Rik,Ac1055,CD130,CDW130,D13Ertd699e,GP130,HIES4,HIES4A,HIES4B,IL-6,IL-6RB,IL6ST,IMD94,sGP130,STWS2 |
| Uniprot Accession | P40189,P40190 |
| Uniprot Entry Name | IL6RB_HUMAN,IL6RB_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Mucocutaneous lymph node syndrome [Kawasaki], breast cancer |
| Gene Ensembl | ENSG00000134352 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL6ST, gene name: IL6ST, also named as CD130, CDW130, GP130, IL-6RB. The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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