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Anti-I17RB/ IL17RB/ CRL4 monoclonal antibody
Anti-I17RB/ IL17RB/ CRL4 antibody for FACS & in-vivo assay
Go to IL17RB/IL17RB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA074-Ab-1/ GM-Tg-hg-TA074-Ab-2 | Anti-Human IL17RB monoclonal antibody | Human |
| GM-Tg-rg-TA074-Ab-1/ GM-Tg-rg-TA074-Ab-2 | Anti-Rat IL17RB monoclonal antibody | Rat |
| GM-Tg-mg-TA074-Ab-1/ GM-Tg-mg-TA074-Ab-2 | Anti-Mouse IL17RB monoclonal antibody | Mouse |
| GM-Tg-cynog-TA074-Ab-1/ GM-Tg-cynog-TA074-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL17RB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA074-Ab-1/ GM-Tg-felg-TA074-Ab-2 | Anti-Feline IL17RB monoclonal antibody | Feline |
| GM-Tg-cang-TA074-Ab-1/ GM-Tg-cang-TA074-Ab-2 | Anti-Canine IL17RB monoclonal antibody | Canine |
| GM-Tg-bovg-TA074-Ab-1/ GM-Tg-bovg-TA074-Ab-2 | Anti-Bovine IL17RB monoclonal antibody | Bovine |
| GM-Tg-equg-TA074-Ab-1/ GM-Tg-equg-TA074-Ab-2 | Anti-Equine IL17RB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA074-Ab-1/ GM-Tg-hg-TA074-Ab-2; GM-Tg-rg-TA074-Ab-1/ GM-Tg-rg-TA074-Ab-2; GM-Tg-mg-TA074-Ab-1/ GM-Tg-mg-TA074-Ab-2; GM-Tg-cynog-TA074-Ab-1/ GM-Tg-cynog-TA074-Ab-2; GM-Tg-felg-TA074-Ab-1/ GM-Tg-felg-TA074-Ab-2; GM-Tg-cang-TA074-Ab-1/ GM-Tg-cang-TA074-Ab-2; GM-Tg-bovg-TA074-Ab-1/ GM-Tg-bovg-TA074-Ab-2; GM-Tg-equg-TA074-Ab-1/ GM-Tg-equg-TA074-Ab-2 |
| Products Name | Anti-IL17RB monoclonal antibody |
| Format | mab |
| Target Name | IL17RB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL17RB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I17RB/ IL17RB/ CRL4 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-TA074-Ag-1 | interleukin 17 receptor B (IL17RB) protein |
| ORF Viral Vector | vGMLP001667 | human IL17RB Lentivirus particle |
| ORF Viral Vector | pGMLP001667 | human IL17RB Lentivirus plasmid |
Target information
| Target ID | GM-TA074 |
| Target Name | IL17RB |
| Gene ID | 55540,50905,306247,693671,476587,101080437,533605,100059421 |
| Gene Symbol and Synonyms | CRL4,EVI27,IL-17ER,IL-17Rh1,IL17BR,IL17RB,IL17RH1 |
| Uniprot Accession | Q9NRM6 |
| Uniprot Entry Name | I17RB_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000056736 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL17RB, gene name: IL17RB, also named as CRL4, EVI27, IL17BR, IL17RH1. The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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