Anti-ITA2B/ ITGA2B/ BDPLT16 monoclonal antibody

Anti-ITA2B/ ITGA2B/ BDPLT16 antibody for FACS & in-vivo assay

Target products collectionGo to ITGA2B/ITGA2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-TA029-Ab-1/ GM-Tg-hg-TA029-Ab-2Anti-Human ITGA2B monoclonal antibodyHuman
GM-Tg-rg-TA029-Ab-1/ GM-Tg-rg-TA029-Ab-2Anti-Rat ITGA2B monoclonal antibodyRat
GM-Tg-mg-TA029-Ab-1/ GM-Tg-mg-TA029-Ab-2Anti-Mouse ITGA2B monoclonal antibodyMouse
GM-Tg-cynog-TA029-Ab-1/ GM-Tg-cynog-TA029-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGA2B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-TA029-Ab-1/ GM-Tg-felg-TA029-Ab-2Anti-Feline ITGA2B monoclonal antibodyFeline
GM-Tg-cang-TA029-Ab-1/ GM-Tg-cang-TA029-Ab-2Anti-Canine ITGA2B monoclonal antibodyCanine
GM-Tg-bovg-TA029-Ab-1/ GM-Tg-bovg-TA029-Ab-2Anti-Bovine ITGA2B monoclonal antibodyBovine
GM-Tg-equg-TA029-Ab-1/ GM-Tg-equg-TA029-Ab-2Anti-Equine ITGA2B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-TA029-Ab-1/ GM-Tg-hg-TA029-Ab-2; GM-Tg-rg-TA029-Ab-1/ GM-Tg-rg-TA029-Ab-2;
GM-Tg-mg-TA029-Ab-1/ GM-Tg-mg-TA029-Ab-2; GM-Tg-cynog-TA029-Ab-1/ GM-Tg-cynog-TA029-Ab-2;
GM-Tg-felg-TA029-Ab-1/ GM-Tg-felg-TA029-Ab-2; GM-Tg-cang-TA029-Ab-1/ GM-Tg-cang-TA029-Ab-2;
GM-Tg-bovg-TA029-Ab-1/ GM-Tg-bovg-TA029-Ab-2; GM-Tg-equg-TA029-Ab-1/ GM-Tg-equg-TA029-Ab-2
Products NameAnti-ITGA2B monoclonal antibody
Formatmab
Target NameITGA2B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGA2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-542Pre-Made Tadocizumab biosimilar, Fab, Anti-ITGA2B;ITGB3 Antibody: Anti-BDPLT16/BDPLT2/CD41/CD41B/GP2B/GPIIb/GT/GT1/GTA/HPA3/PPP1R93;BDPLT16/BDPLT2/BDPLT24/CD61/GP3A/GPIIIa/GT/GT2 therapeutic antibody
    BiosimilarGMP-Bios-INN-713Pre-Made Abciximab Biosimilar, Fab Fusion, Anti-Itga2B/Itgb3 Antibody: Anti-BDPLT16/BDPLT2/CD41/CD41B/GP2B/GPIIb/GT/GT1/GTA/HPA3/PPP1R93;BDPLT16/BDPLT2/BDPLT24/CD61/GP3A/GPIIIa/GT/GT2 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ITA2B/ ITGA2B/ BDPLT16 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-TA029
    Target NameITGA2B
    Gene ID3674,16399,685269,714955,403789,101100930,515011,100009697
    Gene Symbol and SynonymsalphaIIb,BDPLT16,BDPLT2,CD41,CD41B,GP2B,GPIIb,GT,GT1,GTA,HPA3,ITGA2B,PPP1R93
    Uniprot AccessionP08514
    Uniprot Entry NameITA2B_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000005961
    Target ClassificationN/A

    The target: ITGA2B, gene name: ITGA2B, also named as BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93. This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.