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Anti-PRKAA1 monoclonal antibody
Pre-made anti-PRKAA1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PRKAA1/PRKAA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA017-Ab-1/ GM-Tg-hg-TA017-Ab-2 | Anti-Human PRKAA1 monoclonal antibody | Human |
| GM-Tg-rg-TA017-Ab-1/ GM-Tg-rg-TA017-Ab-2 | Anti-Rat PRKAA1 monoclonal antibody | Rat |
| GM-Tg-mg-TA017-Ab-1/ GM-Tg-mg-TA017-Ab-2 | Anti-Mouse PRKAA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-TA017-Ab-1/ GM-Tg-cynog-TA017-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRKAA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA017-Ab-1/ GM-Tg-felg-TA017-Ab-2 | Anti-Feline PRKAA1 monoclonal antibody | Feline |
| GM-Tg-cang-TA017-Ab-1/ GM-Tg-cang-TA017-Ab-2 | Anti-Canine PRKAA1 monoclonal antibody | Canine |
| GM-Tg-bovg-TA017-Ab-1/ GM-Tg-bovg-TA017-Ab-2 | Anti-Bovine PRKAA1 monoclonal antibody | Bovine |
| GM-Tg-equg-TA017-Ab-1/ GM-Tg-equg-TA017-Ab-2 | Anti-Equine PRKAA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA017-Ab-1/ GM-Tg-hg-TA017-Ab-2; GM-Tg-rg-TA017-Ab-1/ GM-Tg-rg-TA017-Ab-2; GM-Tg-mg-TA017-Ab-1/ GM-Tg-mg-TA017-Ab-2; GM-Tg-cynog-TA017-Ab-1/ GM-Tg-cynog-TA017-Ab-2; GM-Tg-felg-TA017-Ab-1/ GM-Tg-felg-TA017-Ab-2; GM-Tg-cang-TA017-Ab-1/ GM-Tg-cang-TA017-Ab-2; GM-Tg-bovg-TA017-Ab-1/ GM-Tg-bovg-TA017-Ab-2; GM-Tg-equg-TA017-Ab-1/ GM-Tg-equg-TA017-Ab-2 |
| Products Name | Anti-PRKAA1 monoclonal antibody |
| Format | mab |
| Target Name | PRKAA1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PRKAA1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-TA017-Ag-1 | Recombinant multi-species AAPK1/ PRKAA1/ AMPK protein |
| ORF Viral Vector | pGMLV000515 | human PRKAA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000577 | human PRKAA1 Lentivirus particle |
| ORF Viral Vector | pGMLV000577 | human PRKAA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000515 | human PRKAA1 Lentivirus particle |
| ORF Viral Vector | pGMLV000482 | pig PRKAA1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003041 | mouse Prkaa1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000482 | pig PRKAA1 Lentivirus particle |
| ORF Viral Vector | vGMLPm003041 | mouse Prkaa1 Lentivirus particle |
Target information
| Target ID | GM-TA017 |
| Target Name | PRKAA1 |
| Gene ID | 5562,105787,65248,695558,479351,101095885,540404,100009710 |
| Gene Symbol and Synonyms | AMPK,AMPK alpha 1,AMPKa1,AMPKalpha1,C130083N04Rik,PRKAA1 |
| Uniprot Accession | Q13131,P54645 |
| Uniprot Entry Name | AAPK1_HUMAN,AAPK1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000132356 |
| Target Classification | Kinase |
The target: PRKAA1, gene name: PRKAA1, also named as AMPK, AMPKa1. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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