Anti-PRKAA1 monoclonal antibody

Pre-made anti-PRKAA1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PRKAA1/PRKAA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-TA017-Ab-1/ GM-Tg-hg-TA017-Ab-2Anti-Human PRKAA1 monoclonal antibodyHuman
GM-Tg-rg-TA017-Ab-1/ GM-Tg-rg-TA017-Ab-2Anti-Rat PRKAA1 monoclonal antibodyRat
GM-Tg-mg-TA017-Ab-1/ GM-Tg-mg-TA017-Ab-2Anti-Mouse PRKAA1 monoclonal antibodyMouse
GM-Tg-cynog-TA017-Ab-1/ GM-Tg-cynog-TA017-Ab-2Anti-Cynomolgus/ Rhesus macaque PRKAA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-TA017-Ab-1/ GM-Tg-felg-TA017-Ab-2Anti-Feline PRKAA1 monoclonal antibodyFeline
GM-Tg-cang-TA017-Ab-1/ GM-Tg-cang-TA017-Ab-2Anti-Canine PRKAA1 monoclonal antibodyCanine
GM-Tg-bovg-TA017-Ab-1/ GM-Tg-bovg-TA017-Ab-2Anti-Bovine PRKAA1 monoclonal antibodyBovine
GM-Tg-equg-TA017-Ab-1/ GM-Tg-equg-TA017-Ab-2Anti-Equine PRKAA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-TA017-Ab-1/ GM-Tg-hg-TA017-Ab-2; GM-Tg-rg-TA017-Ab-1/ GM-Tg-rg-TA017-Ab-2;
GM-Tg-mg-TA017-Ab-1/ GM-Tg-mg-TA017-Ab-2; GM-Tg-cynog-TA017-Ab-1/ GM-Tg-cynog-TA017-Ab-2;
GM-Tg-felg-TA017-Ab-1/ GM-Tg-felg-TA017-Ab-2; GM-Tg-cang-TA017-Ab-1/ GM-Tg-cang-TA017-Ab-2;
GM-Tg-bovg-TA017-Ab-1/ GM-Tg-bovg-TA017-Ab-2; GM-Tg-equg-TA017-Ab-1/ GM-Tg-equg-TA017-Ab-2
Products NameAnti-PRKAA1 monoclonal antibody
Formatmab
Target NamePRKAA1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PRKAA1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-TA017-Ag-1Recombinant multi-species AAPK1/ PRKAA1/ AMPK protein
    ORF Viral VectorpGMLV000515human PRKAA1 Lentivirus plasmid
    ORF Viral VectorvGMLV000577human PRKAA1 Lentivirus particle
    ORF Viral VectorpGMLV000577human PRKAA1 Lentivirus plasmid
    ORF Viral VectorvGMLV000515human PRKAA1 Lentivirus particle
    ORF Viral VectorpGMLV000482pig PRKAA1 Lentivirus plasmid
    ORF Viral VectorpGMLPm003041mouse Prkaa1 Lentivirus plasmid
    ORF Viral VectorvGMLV000482pig PRKAA1 Lentivirus particle
    ORF Viral VectorvGMLPm003041mouse Prkaa1 Lentivirus particle


    Target information

    Target IDGM-TA017
    Target NamePRKAA1
    Gene ID5562,105787,65248,695558,479351,101095885,540404,100009710
    Gene Symbol and SynonymsAMPK,AMPK alpha 1,AMPKa1,AMPKalpha1,C130083N04Rik,PRKAA1
    Uniprot AccessionQ13131,P54645
    Uniprot Entry NameAAPK1_HUMAN,AAPK1_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000132356
    Target ClassificationKinase

    The target: PRKAA1, gene name: PRKAA1, also named as AMPK, AMPKa1. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.