Anti-POLR2A monoclonal antibody

Pre-made anti-POLR2A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to POLR2A/POLR2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-TA016-Ab-1/ GM-Tg-hg-TA016-Ab-2Anti-Human POLR2A monoclonal antibodyHuman
GM-Tg-rg-TA016-Ab-1/ GM-Tg-rg-TA016-Ab-2Anti-Rat POLR2A monoclonal antibodyRat
GM-Tg-mg-TA016-Ab-1/ GM-Tg-mg-TA016-Ab-2Anti-Mouse POLR2A monoclonal antibodyMouse
GM-Tg-cynog-TA016-Ab-1/ GM-Tg-cynog-TA016-Ab-2Anti-Cynomolgus/ Rhesus macaque POLR2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-TA016-Ab-1/ GM-Tg-felg-TA016-Ab-2Anti-Feline POLR2A monoclonal antibodyFeline
GM-Tg-cang-TA016-Ab-1/ GM-Tg-cang-TA016-Ab-2Anti-Canine POLR2A monoclonal antibodyCanine
GM-Tg-bovg-TA016-Ab-1/ GM-Tg-bovg-TA016-Ab-2Anti-Bovine POLR2A monoclonal antibodyBovine
GM-Tg-equg-TA016-Ab-1/ GM-Tg-equg-TA016-Ab-2Anti-Equine POLR2A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-TA016-Ab-1/ GM-Tg-hg-TA016-Ab-2; GM-Tg-rg-TA016-Ab-1/ GM-Tg-rg-TA016-Ab-2;
GM-Tg-mg-TA016-Ab-1/ GM-Tg-mg-TA016-Ab-2; GM-Tg-cynog-TA016-Ab-1/ GM-Tg-cynog-TA016-Ab-2;
GM-Tg-felg-TA016-Ab-1/ GM-Tg-felg-TA016-Ab-2; GM-Tg-cang-TA016-Ab-1/ GM-Tg-cang-TA016-Ab-2;
GM-Tg-bovg-TA016-Ab-1/ GM-Tg-bovg-TA016-Ab-2; GM-Tg-equg-TA016-Ab-1/ GM-Tg-equg-TA016-Ab-2
Products NameAnti-POLR2A monoclonal antibody
Formatmab
Target NamePOLR2A
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-POLR2A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-TA016-Ag-1Recombinant multi-species RPB1/ POLR2A/ POLR2 protein


    Target information

    Target IDGM-TA016
    Target NamePOLR2A
    Gene ID5430,20020,363633,721865,479483,101098500,282312,100072997
    Gene Symbol and Synonyms220kDa,hRPB220,hsRPB1,NEDHIB,POLR2,POLR2A,POLRA,RPB1,RPBh1,RpIILS,RPO2,Rpo2-1,RPOL2
    Uniprot AccessionP24928
    Uniprot Entry NameRPB1_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000181222
    Target ClassificationN/A

    The target: POLR2A, gene name: POLR2A, also named as POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1. This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.