- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PD1L1/ PD-L1/ CD274 monoclonal antibody
Anti-PD1L1/ PD-L1/ CD274 antibody for FACS & in-vivo assay
Go to PD-L1/CD274 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T99948-Ab-1/ GM-Tg-hg-T99948-Ab-2 | Anti-Human PD-L1/CD274 monoclonal antibody | Human |
| GM-Tg-rg-T99948-Ab-1/ GM-Tg-rg-T99948-Ab-2 | Anti-Rat PD-L1/CD274 monoclonal antibody | Rat |
| GM-Tg-mg-T99948-Ab-1/ GM-Tg-mg-T99948-Ab-2 | Anti-Mouse PD-L1/CD274 monoclonal antibody | Mouse |
| GM-Tg-cynog-T99948-Ab-1/ GM-Tg-cynog-T99948-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PD-L1/CD274 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T99948-Ab-1/ GM-Tg-felg-T99948-Ab-2 | Anti-Feline PD-L1/CD274 monoclonal antibody | Feline |
| GM-Tg-cang-T99948-Ab-1/ GM-Tg-cang-T99948-Ab-2 | Anti-Canine PD-L1/CD274 monoclonal antibody | Canine |
| GM-Tg-bovg-T99948-Ab-1/ GM-Tg-bovg-T99948-Ab-2 | Anti-Bovine PD-L1/CD274 monoclonal antibody | Bovine |
| GM-Tg-equg-T99948-Ab-1/ GM-Tg-equg-T99948-Ab-2 | Anti-Equine PD-L1/CD274 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T99948-Ab-1/ GM-Tg-hg-T99948-Ab-2; GM-Tg-rg-T99948-Ab-1/ GM-Tg-rg-T99948-Ab-2; GM-Tg-mg-T99948-Ab-1/ GM-Tg-mg-T99948-Ab-2; GM-Tg-cynog-T99948-Ab-1/ GM-Tg-cynog-T99948-Ab-2; GM-Tg-felg-T99948-Ab-1/ GM-Tg-felg-T99948-Ab-2; GM-Tg-cang-T99948-Ab-1/ GM-Tg-cang-T99948-Ab-2; GM-Tg-bovg-T99948-Ab-1/ GM-Tg-bovg-T99948-Ab-2; GM-Tg-equg-T99948-Ab-1/ GM-Tg-equg-T99948-Ab-2 |
| Products Name | Anti-PD-L1/CD274 monoclonal antibody |
| Format | mab |
| Target Name | PD-L1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PD-L1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T99948 |
| Target Name | PD-L1 |
| Gene ID | 29126,60533,499342,716043,484186,100127110,533834,100051703 |
| Gene Symbol and Synonyms | A530045L16Rik,B7-H,B7H1,CD274,hPD-L1,PD-L1,PDCD1L1,PDCD1LG1,PDL1,RGD1566211 |
| Uniprot Accession | Q9NZQ7 |
| Uniprot Entry Name | PD1L1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000120217 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: PD-L1, gene name: CD274, also named as B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1. This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
