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Anti-CHLE/ BCHE/ BCHED monoclonal antibody
Anti-CHLE/ BCHE/ BCHED antibody for FACS & in-vivo assay
Go to BCHE/BCHE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T99799-Ab-1/ GM-Tg-hg-T99799-Ab-2 | Anti-Human BCHE monoclonal antibody | Human |
| GM-Tg-rg-T99799-Ab-1/ GM-Tg-rg-T99799-Ab-2 | Anti-Rat BCHE monoclonal antibody | Rat |
| GM-Tg-mg-T99799-Ab-1/ GM-Tg-mg-T99799-Ab-2 | Anti-Mouse BCHE monoclonal antibody | Mouse |
| GM-Tg-cynog-T99799-Ab-1/ GM-Tg-cynog-T99799-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCHE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T99799-Ab-1/ GM-Tg-felg-T99799-Ab-2 | Anti-Feline BCHE monoclonal antibody | Feline |
| GM-Tg-cang-T99799-Ab-1/ GM-Tg-cang-T99799-Ab-2 | Anti-Canine BCHE monoclonal antibody | Canine |
| GM-Tg-bovg-T99799-Ab-1/ GM-Tg-bovg-T99799-Ab-2 | Anti-Bovine BCHE monoclonal antibody | Bovine |
| GM-Tg-equg-T99799-Ab-1/ GM-Tg-equg-T99799-Ab-2 | Anti-Equine BCHE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T99799-Ab-1/ GM-Tg-hg-T99799-Ab-2; GM-Tg-rg-T99799-Ab-1/ GM-Tg-rg-T99799-Ab-2; GM-Tg-mg-T99799-Ab-1/ GM-Tg-mg-T99799-Ab-2; GM-Tg-cynog-T99799-Ab-1/ GM-Tg-cynog-T99799-Ab-2; GM-Tg-felg-T99799-Ab-1/ GM-Tg-felg-T99799-Ab-2; GM-Tg-cang-T99799-Ab-1/ GM-Tg-cang-T99799-Ab-2; GM-Tg-bovg-T99799-Ab-1/ GM-Tg-bovg-T99799-Ab-2; GM-Tg-equg-T99799-Ab-1/ GM-Tg-equg-T99799-Ab-2 |
| Products Name | Anti-BCHE monoclonal antibody |
| Format | mab |
| Target Name | BCHE |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BCHE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CHLE/ BCHE/ BCHED VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005340 | mouse Bche Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005340 | mouse Bche Lentivirus particle |
Target information
| Target ID | GM-T99799 |
| Target Name | BCHE |
| Gene ID | 590,12038,65036,700484,488143,493960,534616,100033901 |
| Gene Symbol and Synonyms | BCHE,BCHED,C730038G20Rik,CHE1,CHE2,E1,EQ-BCHE |
| Uniprot Accession | P06276,P32751,P32750,O62760,P32749,P81908 |
| Uniprot Entry Name | CHLE_HUMAN,CHLE_MACMU,CHLE_FELCA,CHLE_CANLF,CHLE_BOVIN,CHLE_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer, Neurological effects, OP toxicity |
| Gene Ensembl | ENSG00000114200 |
| Target Classification | N/A |
The target: BCHE, gene name: BCHE, also named as BCHED, CHE1, CHE2, E1. This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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