Anti-FGF18/ FGF-18/ ZFGF5 functional antibody

Anti-FGF18/ FGF-18/ ZFGF5 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to FGF18/FGF18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T99732-Ab-1/ GM-Tg-hg-T99732-Ab-2Anti-Human FGF18 monoclonal antibodyHuman
GM-Tg-rg-T99732-Ab-1/ GM-Tg-rg-T99732-Ab-2Anti-Rat FGF18 monoclonal antibodyRat
GM-Tg-mg-T99732-Ab-1/ GM-Tg-mg-T99732-Ab-2Anti-Mouse FGF18 monoclonal antibodyMouse
GM-Tg-cynog-T99732-Ab-1/ GM-Tg-cynog-T99732-Ab-2Anti-Cynomolgus/ Rhesus macaque FGF18 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T99732-Ab-1/ GM-Tg-felg-T99732-Ab-2Anti-Feline FGF18 monoclonal antibodyFeline
GM-Tg-cang-T99732-Ab-1/ GM-Tg-cang-T99732-Ab-2Anti-Canine FGF18 monoclonal antibodyCanine
GM-Tg-bovg-T99732-Ab-1/ GM-Tg-bovg-T99732-Ab-2Anti-Bovine FGF18 monoclonal antibodyBovine
GM-Tg-equg-T99732-Ab-1/ GM-Tg-equg-T99732-Ab-2Anti-Equine FGF18 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T99732-Ab-1/ GM-Tg-hg-T99732-Ab-2; GM-Tg-rg-T99732-Ab-1/ GM-Tg-rg-T99732-Ab-2;
GM-Tg-mg-T99732-Ab-1/ GM-Tg-mg-T99732-Ab-2; GM-Tg-cynog-T99732-Ab-1/ GM-Tg-cynog-T99732-Ab-2;
GM-Tg-felg-T99732-Ab-1/ GM-Tg-felg-T99732-Ab-2; GM-Tg-cang-T99732-Ab-1/ GM-Tg-cang-T99732-Ab-2;
GM-Tg-bovg-T99732-Ab-1/ GM-Tg-bovg-T99732-Ab-2; GM-Tg-equg-T99732-Ab-1/ GM-Tg-equg-T99732-Ab-2
Products NameAnti-FGF18 monoclonal antibody
Formatmab
Target NameFGF18
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FGF18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T99732-Ag-1Recombinant multi-species FGF18/ FGF-18/ ZFGF5 protein
    CytokineGM-Tg-g-T99732-Ag-1fibroblast growth factor 18 (FGF18) protein
    ORF Viral VectorpGMLP000468human FGF18 Lentivirus plasmid
    ORF Viral VectorvGMAP000362Human FGF18 Adenovirus particle
    ORF Viral VectorvGMLP000468human FGF18 Lentivirus particle
    ORF Viral VectorpGMAP000362Human FGF18 Adenovirus plasmid
    ORF Viral VectorpGMLPm004509mouse Fgf18 Lentivirus plasmid
    ORF Viral VectorvGMLPm004509mouse Fgf18 Lentivirus particle


    Target information

    Target IDGM-T99732
    Target NameFGF18
    Gene ID8817,14172,29369,702072,611641,101098518,533929,100629648
    Gene Symbol and SynonymsD130055P09Rik,FGF-18,FGF18,Fgf6a,ZFGF5
    Uniprot AccessionO76093,O88182,Q0VCA0
    Uniprot Entry NameFGF18_HUMAN,FGF18_RAT,FGF18_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000156427
    Target ClassificationN/A

    The target: FGF18, gene name: FGF18, also named as FGF-18, ZFGF5. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.