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Anti-NTCP/ SLC10A1 monoclonal antibody
Anti-NTCP/ SLC10A1 antibody for FACS & in-vivo assay
Go to SLC10A1/SLC10A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T99189-Ab-1/ GM-Tg-hg-T99189-Ab-2 | Anti-Human SLC10A1 monoclonal antibody | Human |
| GM-Tg-rg-T99189-Ab-1/ GM-Tg-rg-T99189-Ab-2 | Anti-Rat SLC10A1 monoclonal antibody | Rat |
| GM-Tg-mg-T99189-Ab-1/ GM-Tg-mg-T99189-Ab-2 | Anti-Mouse SLC10A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T99189-Ab-1/ GM-Tg-cynog-T99189-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC10A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T99189-Ab-1/ GM-Tg-felg-T99189-Ab-2 | Anti-Feline SLC10A1 monoclonal antibody | Feline |
| GM-Tg-cang-T99189-Ab-1/ GM-Tg-cang-T99189-Ab-2 | Anti-Canine SLC10A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T99189-Ab-1/ GM-Tg-bovg-T99189-Ab-2 | Anti-Bovine SLC10A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T99189-Ab-1/ GM-Tg-equg-T99189-Ab-2 | Anti-Equine SLC10A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T99189-Ab-1/ GM-Tg-hg-T99189-Ab-2; GM-Tg-rg-T99189-Ab-1/ GM-Tg-rg-T99189-Ab-2; GM-Tg-mg-T99189-Ab-1/ GM-Tg-mg-T99189-Ab-2; GM-Tg-cynog-T99189-Ab-1/ GM-Tg-cynog-T99189-Ab-2; GM-Tg-felg-T99189-Ab-1/ GM-Tg-felg-T99189-Ab-2; GM-Tg-cang-T99189-Ab-1/ GM-Tg-cang-T99189-Ab-2; GM-Tg-bovg-T99189-Ab-1/ GM-Tg-bovg-T99189-Ab-2; GM-Tg-equg-T99189-Ab-1/ GM-Tg-equg-T99189-Ab-2 |
| Products Name | Anti-SLC10A1 monoclonal antibody |
| Format | mab |
| Target Name | SLC10A1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC10A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NTCP/ SLC10A1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000268 | human SLC10A1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000268 | human SLC10A1 Lentivirus particle |
| ORF Viral Vector | pGMAP000375 | Human SLC10A1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000375 | Human SLC10A1 Adenovirus particle |
| ORF Viral Vector | pGMLPm001496 | mouse Slc10a1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001496 | mouse Slc10a1 Lentivirus particle |
Target information
| Target ID | GM-T99189 |
| Target Name | SLC10A1 |
| Gene ID | 6554,20493,24777,712925,480372,101080544,532890,100064290 |
| Gene Symbol and Synonyms | FHCA2,NTCP,Ntcp1,SBACT,SLC10A1 |
| Uniprot Accession | Q14973,P26435 |
| Uniprot Entry Name | NTCP_HUMAN,NTCP_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000100652 |
| Target Classification | N/A |
The target: SLC10A1, gene name: SLC10A1, also named as NTCP. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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