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Anti-PBK monoclonal antibody
Pre-made anti-PBK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PBK/PBK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T98642-Ab-1/ GM-Tg-hg-T98642-Ab-2 | Anti-Human PBK monoclonal antibody | Human |
| GM-Tg-rg-T98642-Ab-1/ GM-Tg-rg-T98642-Ab-2 | Anti-Rat PBK monoclonal antibody | Rat |
| GM-Tg-mg-T98642-Ab-1/ GM-Tg-mg-T98642-Ab-2 | Anti-Mouse PBK monoclonal antibody | Mouse |
| GM-Tg-cynog-T98642-Ab-1/ GM-Tg-cynog-T98642-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PBK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T98642-Ab-1/ GM-Tg-felg-T98642-Ab-2 | Anti-Feline PBK monoclonal antibody | Feline |
| GM-Tg-cang-T98642-Ab-1/ GM-Tg-cang-T98642-Ab-2 | Anti-Canine PBK monoclonal antibody | Canine |
| GM-Tg-bovg-T98642-Ab-1/ GM-Tg-bovg-T98642-Ab-2 | Anti-Bovine PBK monoclonal antibody | Bovine |
| GM-Tg-equg-T98642-Ab-1/ GM-Tg-equg-T98642-Ab-2 | Anti-Equine PBK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T98642-Ab-1/ GM-Tg-hg-T98642-Ab-2; GM-Tg-rg-T98642-Ab-1/ GM-Tg-rg-T98642-Ab-2; GM-Tg-mg-T98642-Ab-1/ GM-Tg-mg-T98642-Ab-2; GM-Tg-cynog-T98642-Ab-1/ GM-Tg-cynog-T98642-Ab-2; GM-Tg-felg-T98642-Ab-1/ GM-Tg-felg-T98642-Ab-2; GM-Tg-cang-T98642-Ab-1/ GM-Tg-cang-T98642-Ab-2; GM-Tg-bovg-T98642-Ab-1/ GM-Tg-bovg-T98642-Ab-2; GM-Tg-equg-T98642-Ab-1/ GM-Tg-equg-T98642-Ab-2 |
| Products Name | Anti-PBK monoclonal antibody |
| Format | mab |
| Target Name | PBK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PBK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T98642-Ag-1 | Recombinant multi-species TOPK/ PBK/ CT84 protein |
| ORF Viral Vector | pGMLV000097 | human PBK Lentivirus plasmid |
| ORF Viral Vector | vGMLV000097 | human PBK Lentivirus particle |
| ORF Viral Vector | pGMLPm000322 | mouse Pbk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000322 | mouse Pbk Lentivirus particle |
Target information
| Target ID | GM-T98642 |
| Target Name | PBK |
| Gene ID | 55872,52033,290326,713242,477371,101080784,534781,100060789 |
| Gene Symbol and Synonyms | 2810434B10Rik,CT84,D14Ertd732e,HEL164,Nori-3,PBK,SPK,TOPK |
| Uniprot Accession | Q96KB5 |
| Uniprot Entry Name | TOPK_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000168078 |
| Target Classification | N/A |
The target: PBK, gene name: PBK, also named as CT84, HEL164, Nori-3, SPK, TOPK. This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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