Anti-CCR9/ CC-CKR-9/ CDw199 monoclonal antibody

Anti-CCR9/ CC-CKR-9/ CDw199 antibody for FACS & in-vivo assay

Target products collectionGo to CCR9/CCR9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T97873-Ab-1/ GM-Tg-hg-T97873-Ab-2Anti-Human CCR9 monoclonal antibodyHuman
GM-Tg-rg-T97873-Ab-1/ GM-Tg-rg-T97873-Ab-2Anti-Rat CCR9 monoclonal antibodyRat
GM-Tg-mg-T97873-Ab-1/ GM-Tg-mg-T97873-Ab-2Anti-Mouse CCR9 monoclonal antibodyMouse
GM-Tg-cynog-T97873-Ab-1/ GM-Tg-cynog-T97873-Ab-2Anti-Cynomolgus/ Rhesus macaque CCR9 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T97873-Ab-1/ GM-Tg-felg-T97873-Ab-2Anti-Feline CCR9 monoclonal antibodyFeline
GM-Tg-cang-T97873-Ab-1/ GM-Tg-cang-T97873-Ab-2Anti-Canine CCR9 monoclonal antibodyCanine
GM-Tg-bovg-T97873-Ab-1/ GM-Tg-bovg-T97873-Ab-2Anti-Bovine CCR9 monoclonal antibodyBovine
GM-Tg-equg-T97873-Ab-1/ GM-Tg-equg-T97873-Ab-2Anti-Equine CCR9 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T97873-Ab-1/ GM-Tg-hg-T97873-Ab-2; GM-Tg-rg-T97873-Ab-1/ GM-Tg-rg-T97873-Ab-2;
GM-Tg-mg-T97873-Ab-1/ GM-Tg-mg-T97873-Ab-2; GM-Tg-cynog-T97873-Ab-1/ GM-Tg-cynog-T97873-Ab-2;
GM-Tg-felg-T97873-Ab-1/ GM-Tg-felg-T97873-Ab-2; GM-Tg-cang-T97873-Ab-1/ GM-Tg-cang-T97873-Ab-2;
GM-Tg-bovg-T97873-Ab-1/ GM-Tg-bovg-T97873-Ab-2; GM-Tg-equg-T97873-Ab-1/ GM-Tg-equg-T97873-Ab-2
Products NameAnti-CCR9 monoclonal antibody
Formatmab
Target NameCCR9
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CCR9/ CC-CKR-9/ CDw199 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T97873-Ag-1chemokine (C-C motif) receptor 9 (CCR9) protein
    ORF Viral VectorvGMLV000052human CCR9 Lentivirus particle
    ORF Viral VectorpGMLV000052human CCR9 Lentivirus plasmid
    ORF Viral VectorpGMLPm001974mouse Ccr9 Lentivirus plasmid
    ORF Viral VectorvGMLPm001974mouse Ccr9 Lentivirus particle


    Target information

    Target IDGM-T97873
    Target NameCCR9
    Gene ID10803,12769,282832,713934,484793,101083247,530951,100065535
    Gene Symbol and SynonymsA130091K22Rik,CC-CKR-9,CCR9,CDw199,Cmkbr10,GPR-9-6,GPR28
    Uniprot AccessionP51686
    Uniprot Entry NameCCR9_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000173585
    Target ClassificationCheckpoint-Immuno Oncology, GPCR

    The target: CCR9, gene name: CCR9, also named as CC-CKR-9, CDw199, GPR-9-6, GPR28. The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.