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Anti-CCL3/ G0S19-1/ LD78ALPHA functional antibody
Anti-CCL3/ G0S19-1/ LD78ALPHA functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL3/CCL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T97765-Ab-1/ GM-Tg-hg-T97765-Ab-2 | Anti-Human CCL3 monoclonal antibody | Human |
| GM-Tg-rg-T97765-Ab-1/ GM-Tg-rg-T97765-Ab-2 | Anti-Rat CCL3 monoclonal antibody | Rat |
| GM-Tg-mg-T97765-Ab-1/ GM-Tg-mg-T97765-Ab-2 | Anti-Mouse CCL3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T97765-Ab-1/ GM-Tg-cynog-T97765-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T97765-Ab-1/ GM-Tg-felg-T97765-Ab-2 | Anti-Feline CCL3 monoclonal antibody | Feline |
| GM-Tg-cang-T97765-Ab-1/ GM-Tg-cang-T97765-Ab-2 | Anti-Canine CCL3 monoclonal antibody | Canine |
| GM-Tg-bovg-T97765-Ab-1/ GM-Tg-bovg-T97765-Ab-2 | Anti-Bovine CCL3 monoclonal antibody | Bovine |
| GM-Tg-equg-T97765-Ab-1/ GM-Tg-equg-T97765-Ab-2 | Anti-Equine CCL3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T97765-Ab-1/ GM-Tg-hg-T97765-Ab-2; GM-Tg-rg-T97765-Ab-1/ GM-Tg-rg-T97765-Ab-2; GM-Tg-mg-T97765-Ab-1/ GM-Tg-mg-T97765-Ab-2; GM-Tg-cynog-T97765-Ab-1/ GM-Tg-cynog-T97765-Ab-2; GM-Tg-felg-T97765-Ab-1/ GM-Tg-felg-T97765-Ab-2; GM-Tg-cang-T97765-Ab-1/ GM-Tg-cang-T97765-Ab-2; GM-Tg-bovg-T97765-Ab-1/ GM-Tg-bovg-T97765-Ab-2; GM-Tg-equg-T97765-Ab-1/ GM-Tg-equg-T97765-Ab-2 |
| Products Name | Anti-CCL3 monoclonal antibody |
| Format | mab |
| Target Name | CCL3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T97765-Ag-1 | Recombinant multi-species CCL3/ G0S19-1/ LD78ALPHA protein |
| Cytokine | GM-Tg-g-T97765-Ag-1 | chemokine (C-C motif) ligand 3 (CCL3) protein |
| ORF Viral Vector | pGMLP003374 | human CCL3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003374 | human CCL3 Lentivirus particle |
| ORF Viral Vector | pGMLPm001873 | mouse Ccl3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001873 | mouse Ccl3 Lentivirus particle |
Target information
| Target ID | GM-T97765 |
| Target Name | CCL3 |
| Gene ID | 6348 |
| Gene Symbol and Synonyms | CCL3,G0S19-1,LD78ALPHA,MIP-1-alpha,MIP1A,SCYA3 |
| Uniprot Accession | P10147 |
| Uniprot Entry Name | CCL3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000277632 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CCL3, gene name: CCL3, also named as G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3. This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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