Anti-ITA4/ ITGA4/ CD49D monoclonal antibody

Anti-ITA4/ ITGA4/ CD49D antibody for FACS & in-vivo assay

Target products collectionGo to ITGA4/ITGA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T97587-Ab-1/ GM-Tg-hg-T97587-Ab-2Anti-Human ITGA4 monoclonal antibodyHuman
GM-Tg-rg-T97587-Ab-1/ GM-Tg-rg-T97587-Ab-2Anti-Rat ITGA4 monoclonal antibodyRat
GM-Tg-mg-T97587-Ab-1/ GM-Tg-mg-T97587-Ab-2Anti-Mouse ITGA4 monoclonal antibodyMouse
GM-Tg-cynog-T97587-Ab-1/ GM-Tg-cynog-T97587-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGA4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T97587-Ab-1/ GM-Tg-felg-T97587-Ab-2Anti-Feline ITGA4 monoclonal antibodyFeline
GM-Tg-cang-T97587-Ab-1/ GM-Tg-cang-T97587-Ab-2Anti-Canine ITGA4 monoclonal antibodyCanine
GM-Tg-bovg-T97587-Ab-1/ GM-Tg-bovg-T97587-Ab-2Anti-Bovine ITGA4 monoclonal antibodyBovine
GM-Tg-equg-T97587-Ab-1/ GM-Tg-equg-T97587-Ab-2Anti-Equine ITGA4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T97587-Ab-1/ GM-Tg-hg-T97587-Ab-2; GM-Tg-rg-T97587-Ab-1/ GM-Tg-rg-T97587-Ab-2;
GM-Tg-mg-T97587-Ab-1/ GM-Tg-mg-T97587-Ab-2; GM-Tg-cynog-T97587-Ab-1/ GM-Tg-cynog-T97587-Ab-2;
GM-Tg-felg-T97587-Ab-1/ GM-Tg-felg-T97587-Ab-2; GM-Tg-cang-T97587-Ab-1/ GM-Tg-cang-T97587-Ab-2;
GM-Tg-bovg-T97587-Ab-1/ GM-Tg-bovg-T97587-Ab-2; GM-Tg-equg-T97587-Ab-1/ GM-Tg-equg-T97587-Ab-2
Products NameAnti-ITGA4 monoclonal antibody
Formatmab
Target NameITGA4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGA4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-616Pre-Made Vedolizumab biosimilar, Whole mAb, Anti-ITGA4;ITGB7 Antibody: Anti-CD49D/IA4 therapeutic antibody
    BiosimilarGMP-Bios-ab-200Pre-Made Etrolizumab biosimilar, Whole Mab: Anti-ITGA4;ITGB7;ITGAE;ITGB7 therapeutic antibody
    BiosimilarGMP-Bios-ab-005Pre-Made Abrilumab biosimilar, Whole mAb, Anti-α4β7/Integrin alpha 4 beta 7 Antibody: Anti-LPAM‑1 therapeutic antibody
    BiosimilarGMP-Bios-ab-367Pre-Made Natalizumab biosimilar, Whole mAb, Anti-ITGA4 Antibody: Anti-CD49D/IA4 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ITA4/ ITGA4/ CD49D VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T97587
    Target NameITGA4
    Gene ID3676,16401,311144,704745,488429,101081745,282882,100067886
    Gene Symbol and SynonymsCD49D,IA4,ITGA4,Itga4B
    Uniprot AccessionP13612
    Uniprot Entry NameITA4_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000115232
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: ITGA4, gene name: ITGA4, also named as CD49D, IA4. The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.