- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DKK3/ REIC/ RIG functional antibody
Anti-DKK3/ REIC/ RIG functional antibody for cell culture, ELISA & in-vivo assay
Go to DKK3/DKK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96916-Ab-1/ GM-Tg-hg-T96916-Ab-2 | Anti-Human DKK3 monoclonal antibody | Human |
| GM-Tg-rg-T96916-Ab-1/ GM-Tg-rg-T96916-Ab-2 | Anti-Rat DKK3 monoclonal antibody | Rat |
| GM-Tg-mg-T96916-Ab-1/ GM-Tg-mg-T96916-Ab-2 | Anti-Mouse DKK3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96916-Ab-1/ GM-Tg-cynog-T96916-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DKK3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96916-Ab-1/ GM-Tg-felg-T96916-Ab-2 | Anti-Feline DKK3 monoclonal antibody | Feline |
| GM-Tg-cang-T96916-Ab-1/ GM-Tg-cang-T96916-Ab-2 | Anti-Canine DKK3 monoclonal antibody | Canine |
| GM-Tg-bovg-T96916-Ab-1/ GM-Tg-bovg-T96916-Ab-2 | Anti-Bovine DKK3 monoclonal antibody | Bovine |
| GM-Tg-equg-T96916-Ab-1/ GM-Tg-equg-T96916-Ab-2 | Anti-Equine DKK3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96916-Ab-1/ GM-Tg-hg-T96916-Ab-2; GM-Tg-rg-T96916-Ab-1/ GM-Tg-rg-T96916-Ab-2; GM-Tg-mg-T96916-Ab-1/ GM-Tg-mg-T96916-Ab-2; GM-Tg-cynog-T96916-Ab-1/ GM-Tg-cynog-T96916-Ab-2; GM-Tg-felg-T96916-Ab-1/ GM-Tg-felg-T96916-Ab-2; GM-Tg-cang-T96916-Ab-1/ GM-Tg-cang-T96916-Ab-2; GM-Tg-bovg-T96916-Ab-1/ GM-Tg-bovg-T96916-Ab-2; GM-Tg-equg-T96916-Ab-1/ GM-Tg-equg-T96916-Ab-2 |
| Products Name | Anti-DKK3 monoclonal antibody |
| Format | mab |
| Target Name | DKK3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DKK3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T96916-Ag-1 | Recombinant multi-species DKK3/ REIC/ RIG protein |
| ORF Viral Vector | vGMLP004070 | human DKK3 Lentivirus particle |
| ORF Viral Vector | pGMLP004070 | human DKK3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002163 | mouse Dkk3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002164 | mouse Dkk3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005424 | mouse Dkk3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002163 | mouse Dkk3 Lentivirus particle |
| ORF Viral Vector | vGMLPm002164 | mouse Dkk3 Lentivirus particle |
| ORF Viral Vector | vGMLPm005424 | mouse Dkk3 Lentivirus particle |
Target information
| Target ID | GM-T96916 |
| Target Name | DKK3 |
| Gene ID | 27122,50781,171548,701549,476857,101093392,506627,100055937 |
| Gene Symbol and Synonyms | CRRL,dkk-3,DKK3,mDkk-3,p29,REIC,REIC/Dkk-3,RIG |
| Uniprot Accession | Q9UBP4 |
| Uniprot Entry Name | DKK3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000050165 |
| Target Classification | N/A |
The target: DKK3, gene name: DKK3, also named as REIC, RIG. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
