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Anti-LIFR/ CD118/ LIF-R monoclonal antibody
Anti-LIFR/ CD118/ LIF-R antibody for FACS & in-vivo assay
Go to LIFR/LIFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96894-Ab-1/ GM-Tg-hg-T96894-Ab-2 | Anti-Human LIFR monoclonal antibody | Human |
| GM-Tg-rg-T96894-Ab-1/ GM-Tg-rg-T96894-Ab-2 | Anti-Rat LIFR monoclonal antibody | Rat |
| GM-Tg-mg-T96894-Ab-1/ GM-Tg-mg-T96894-Ab-2 | Anti-Mouse LIFR monoclonal antibody | Mouse |
| GM-Tg-cynog-T96894-Ab-1/ GM-Tg-cynog-T96894-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LIFR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96894-Ab-1/ GM-Tg-felg-T96894-Ab-2 | Anti-Feline LIFR monoclonal antibody | Feline |
| GM-Tg-cang-T96894-Ab-1/ GM-Tg-cang-T96894-Ab-2 | Anti-Canine LIFR monoclonal antibody | Canine |
| GM-Tg-bovg-T96894-Ab-1/ GM-Tg-bovg-T96894-Ab-2 | Anti-Bovine LIFR monoclonal antibody | Bovine |
| GM-Tg-equg-T96894-Ab-1/ GM-Tg-equg-T96894-Ab-2 | Anti-Equine LIFR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96894-Ab-1/ GM-Tg-hg-T96894-Ab-2; GM-Tg-rg-T96894-Ab-1/ GM-Tg-rg-T96894-Ab-2; GM-Tg-mg-T96894-Ab-1/ GM-Tg-mg-T96894-Ab-2; GM-Tg-cynog-T96894-Ab-1/ GM-Tg-cynog-T96894-Ab-2; GM-Tg-felg-T96894-Ab-1/ GM-Tg-felg-T96894-Ab-2; GM-Tg-cang-T96894-Ab-1/ GM-Tg-cang-T96894-Ab-2; GM-Tg-bovg-T96894-Ab-1/ GM-Tg-bovg-T96894-Ab-2; GM-Tg-equg-T96894-Ab-1/ GM-Tg-equg-T96894-Ab-2 |
| Products Name | Anti-LIFR monoclonal antibody |
| Format | mab |
| Target Name | LIFR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LIFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LIFR/ CD118/ LIF-R VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T96894-Ag-1 | leukemia inhibitory factor receptor (LIFR) protein |
Target information
| Target ID | GM-T96894 |
| Target Name | LIFR |
| Gene ID | 3977,16880,81680,694139,449478,101097206,539504,100066903 |
| Gene Symbol and Synonyms | A230075M04Rik,CD118,LIF,LIF-R,LIFR,SJS2,STWS,SWS |
| Uniprot Accession | P42702,O70535,Q5XNR9 |
| Uniprot Entry Name | LIFR_HUMAN,LIFR_RAT,LIFR_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000113594 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LIFR, gene name: LIFR, also named as CD118, LIF-R, SJS2, STWS, SWS. This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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