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Anti-IL37/ FIL1/ FIL1(ZETA) functional antibody
Anti-IL37/ FIL1/ FIL1(ZETA) functional antibody for cell culture, ELISA & in-vivo assay
Go to IL37/IL37 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96845-Ab-1/ GM-Tg-hg-T96845-Ab-2 | Anti-Human IL37 monoclonal antibody | Human |
| GM-Tg-rg-T96845-Ab-1/ GM-Tg-rg-T96845-Ab-2 | Anti-Rat IL37 monoclonal antibody | Rat |
| GM-Tg-mg-T96845-Ab-1/ GM-Tg-mg-T96845-Ab-2 | Anti-Mouse IL37 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96845-Ab-1/ GM-Tg-cynog-T96845-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL37 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96845-Ab-1/ GM-Tg-felg-T96845-Ab-2 | Anti-Feline IL37 monoclonal antibody | Feline |
| GM-Tg-cang-T96845-Ab-1/ GM-Tg-cang-T96845-Ab-2 | Anti-Canine IL37 monoclonal antibody | Canine |
| GM-Tg-bovg-T96845-Ab-1/ GM-Tg-bovg-T96845-Ab-2 | Anti-Bovine IL37 monoclonal antibody | Bovine |
| GM-Tg-equg-T96845-Ab-1/ GM-Tg-equg-T96845-Ab-2 | Anti-Equine IL37 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96845-Ab-1/ GM-Tg-hg-T96845-Ab-2; GM-Tg-rg-T96845-Ab-1/ GM-Tg-rg-T96845-Ab-2; GM-Tg-mg-T96845-Ab-1/ GM-Tg-mg-T96845-Ab-2; GM-Tg-cynog-T96845-Ab-1/ GM-Tg-cynog-T96845-Ab-2; GM-Tg-felg-T96845-Ab-1/ GM-Tg-felg-T96845-Ab-2; GM-Tg-cang-T96845-Ab-1/ GM-Tg-cang-T96845-Ab-2; GM-Tg-bovg-T96845-Ab-1/ GM-Tg-bovg-T96845-Ab-2; GM-Tg-equg-T96845-Ab-1/ GM-Tg-equg-T96845-Ab-2 |
| Products Name | Anti-IL37 monoclonal antibody |
| Format | mab |
| Target Name | IL37 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL37 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T96845-Ag-1 | Recombinant multi-species IL37/ FIL1/ FIL1(ZETA) protein |
| Cytokine | GM-Tg-g-T96845-Ag-1 | interleukin 37 (IL37) protein |
| ORF Viral Vector | vGMAP000269 | Human IL1F7 Adenovirus particle |
| ORF Viral Vector | pGMAP000269 | Human IL1F7 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000120 | human IL37 Lentivirus particle |
| ORF Viral Vector | pGMLV000120 | human IL37 Lentivirus plasmid |
Target information
| Target ID | GM-T96845 |
| Target Name | IL37 |
| Gene ID | 27178,700579,786493,100052470 |
| Gene Symbol and Synonyms | FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-23,IL-37,IL1F7,IL1H4,IL1RP1,IL37 |
| Uniprot Accession | Q9NZH6 |
| Uniprot Entry Name | IL37_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000125571 |
| Target Classification | N/A |
The target: IL37, gene name: IL37, also named as FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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