Anti-GDF5/ GDF-5/ BDA1C monoclonal antibody

Anti-GDF5/ GDF-5/ BDA1C antibody for FACS & in-vivo assay

Target products collectionGo to GDF-5/GDF5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T96760-Ab-1/ GM-Tg-hg-T96760-Ab-2Anti-Human GDF-5/GDF5 monoclonal antibodyHuman
GM-Tg-rg-T96760-Ab-1/ GM-Tg-rg-T96760-Ab-2Anti-Rat GDF-5/GDF5 monoclonal antibodyRat
GM-Tg-mg-T96760-Ab-1/ GM-Tg-mg-T96760-Ab-2Anti-Mouse GDF-5/GDF5 monoclonal antibodyMouse
GM-Tg-cynog-T96760-Ab-1/ GM-Tg-cynog-T96760-Ab-2Anti-Cynomolgus/ Rhesus macaque GDF-5/GDF5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T96760-Ab-1/ GM-Tg-felg-T96760-Ab-2Anti-Feline GDF-5/GDF5 monoclonal antibodyFeline
GM-Tg-cang-T96760-Ab-1/ GM-Tg-cang-T96760-Ab-2Anti-Canine GDF-5/GDF5 monoclonal antibodyCanine
GM-Tg-bovg-T96760-Ab-1/ GM-Tg-bovg-T96760-Ab-2Anti-Bovine GDF-5/GDF5 monoclonal antibodyBovine
GM-Tg-equg-T96760-Ab-1/ GM-Tg-equg-T96760-Ab-2Anti-Equine GDF-5/GDF5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T96760-Ab-1/ GM-Tg-hg-T96760-Ab-2; GM-Tg-rg-T96760-Ab-1/ GM-Tg-rg-T96760-Ab-2;
GM-Tg-mg-T96760-Ab-1/ GM-Tg-mg-T96760-Ab-2; GM-Tg-cynog-T96760-Ab-1/ GM-Tg-cynog-T96760-Ab-2;
GM-Tg-felg-T96760-Ab-1/ GM-Tg-felg-T96760-Ab-2; GM-Tg-cang-T96760-Ab-1/ GM-Tg-cang-T96760-Ab-2;
GM-Tg-bovg-T96760-Ab-1/ GM-Tg-bovg-T96760-Ab-2; GM-Tg-equg-T96760-Ab-1/ GM-Tg-equg-T96760-Ab-2
Products NameAnti-GDF-5/GDF5 monoclonal antibody
Formatmab
Target NameGDF-5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GDF-5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GDF5/ GDF-5/ BDA1C VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T96760-Ag-1growth differentiation factor 5 (GDF5) protein
    ORF Viral VectorpGMLP001388human GDF5 Lentivirus plasmid
    ORF Viral VectorvGMLP001388human GDF5 Lentivirus particle
    ORF Viral VectorpGMLPm002972mouse Gdf5 Lentivirus plasmid
    ORF Viral VectorvGMLPm002972mouse Gdf5 Lentivirus particle


    Target information

    Target IDGM-T96760
    Target NameGDF-5
    Gene ID8200,14563,252835,705432,485850,101081533,539559,100034228
    Gene Symbol and SynonymsBDA1C,BMP-14,BMP14,bp,brp,Cdmp-1,CDMP1,DUPANS,GDF5,LAP-4,LAP4,OS5,SYM1B,SYNS2
    Uniprot AccessionP43026
    Uniprot Entry NameGDF5_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000125965
    Target ClassificationN/A

    The target: GDF-5, gene name: GDF5, also named as BDA1C, BMP-14, BMP14, CDMP1, LAP-4, LAP4, OS5, SYM1B, SYNS2. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.