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Anti-HK2 monoclonal antibody
Pre-made anti-HK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HK2/HK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96685-Ab-1/ GM-Tg-hg-T96685-Ab-2 | Anti-Human HK2 monoclonal antibody | Human |
| GM-Tg-rg-T96685-Ab-1/ GM-Tg-rg-T96685-Ab-2 | Anti-Rat HK2 monoclonal antibody | Rat |
| GM-Tg-mg-T96685-Ab-1/ GM-Tg-mg-T96685-Ab-2 | Anti-Mouse HK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T96685-Ab-1/ GM-Tg-cynog-T96685-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96685-Ab-1/ GM-Tg-felg-T96685-Ab-2 | Anti-Feline HK2 monoclonal antibody | Feline |
| GM-Tg-cang-T96685-Ab-1/ GM-Tg-cang-T96685-Ab-2 | Anti-Canine HK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T96685-Ab-1/ GM-Tg-bovg-T96685-Ab-2 | Anti-Bovine HK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T96685-Ab-1/ GM-Tg-equg-T96685-Ab-2 | Anti-Equine HK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96685-Ab-1/ GM-Tg-hg-T96685-Ab-2; GM-Tg-rg-T96685-Ab-1/ GM-Tg-rg-T96685-Ab-2; GM-Tg-mg-T96685-Ab-1/ GM-Tg-mg-T96685-Ab-2; GM-Tg-cynog-T96685-Ab-1/ GM-Tg-cynog-T96685-Ab-2; GM-Tg-felg-T96685-Ab-1/ GM-Tg-felg-T96685-Ab-2; GM-Tg-cang-T96685-Ab-1/ GM-Tg-cang-T96685-Ab-2; GM-Tg-bovg-T96685-Ab-1/ GM-Tg-bovg-T96685-Ab-2; GM-Tg-equg-T96685-Ab-1/ GM-Tg-equg-T96685-Ab-2 |
| Products Name | Anti-HK2 monoclonal antibody |
| Format | mab |
| Target Name | HK2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T96685-Ag-1 | Recombinant multi-species HXK2/ HK2/ HKII protein |
Target information
| Target ID | GM-T96685 |
| Target Name | HK2 |
| Gene ID | 3099,15277,25059,710479,100856448,101089344,788926,100009677 |
| Gene Symbol and Synonyms | HK2,HKII,HXK2 |
| Uniprot Accession | P52789,P27881,A2PYL6 |
| Uniprot Entry Name | HXK2_HUMAN,HXK2_RAT,HXK2_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000159399 |
| Target Classification | N/A |
The target: HK2, gene name: HK2, also named as HKII, HXK2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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