Anti-GROA/ CXCL1/ FSP functional antibody

Anti-GROA/ CXCL1/ FSP functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CXCL1/CXCL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T96005-Ab-1/ GM-Tg-hg-T96005-Ab-2Anti-Human CXCL1 monoclonal antibodyHuman
GM-Tg-rg-T96005-Ab-1/ GM-Tg-rg-T96005-Ab-2Anti-Rat CXCL1 monoclonal antibodyRat
GM-Tg-mg-T96005-Ab-1/ GM-Tg-mg-T96005-Ab-2Anti-Mouse CXCL1 monoclonal antibodyMouse
GM-Tg-cynog-T96005-Ab-1/ GM-Tg-cynog-T96005-Ab-2Anti-Cynomolgus/ Rhesus macaque CXCL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T96005-Ab-1/ GM-Tg-felg-T96005-Ab-2Anti-Feline CXCL1 monoclonal antibodyFeline
GM-Tg-cang-T96005-Ab-1/ GM-Tg-cang-T96005-Ab-2Anti-Canine CXCL1 monoclonal antibodyCanine
GM-Tg-bovg-T96005-Ab-1/ GM-Tg-bovg-T96005-Ab-2Anti-Bovine CXCL1 monoclonal antibodyBovine
GM-Tg-equg-T96005-Ab-1/ GM-Tg-equg-T96005-Ab-2Anti-Equine CXCL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T96005-Ab-1/ GM-Tg-hg-T96005-Ab-2; GM-Tg-rg-T96005-Ab-1/ GM-Tg-rg-T96005-Ab-2;
GM-Tg-mg-T96005-Ab-1/ GM-Tg-mg-T96005-Ab-2; GM-Tg-cynog-T96005-Ab-1/ GM-Tg-cynog-T96005-Ab-2;
GM-Tg-felg-T96005-Ab-1/ GM-Tg-felg-T96005-Ab-2; GM-Tg-cang-T96005-Ab-1/ GM-Tg-cang-T96005-Ab-2;
GM-Tg-bovg-T96005-Ab-1/ GM-Tg-bovg-T96005-Ab-2; GM-Tg-equg-T96005-Ab-1/ GM-Tg-equg-T96005-Ab-2
Products NameAnti-CXCL1 monoclonal antibody
Formatmab
Target NameCXCL1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CXCL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T96005-Ag-1Recombinant multi-species GROA/ CXCL1/ FSP protein
    CytokineGM-Tg-g-T96005-Ag-1chemokine (C-X-C motif) ligand 1 (CXCL1) protein
    ORF Viral VectorpGMLP000056human CXCL1 Lentivirus plasmid
    ORF Viral VectorvGMLP000056human CXCL1 Lentivirus particle
    ORF Viral VectorpGMLV000055rat Cxcl1 Lentivirus plasmid
    ORF Viral VectorpGMLV000549Norway rat Cxcl1 Lentivirus plasmid
    ORF Viral VectorpGMLPm000908mouse Cxcl1 Lentivirus plasmid
    ORF Viral VectorvGMLV000055rat Cxcl1 Lentivirus particle
    ORF Viral VectorvGMLV000549Norway rat Cxcl1 Lentivirus particle
    ORF Viral VectorvGMLPm000908mouse Cxcl1 Lentivirus particle


    Target information

    Target IDGM-T96005
    Target NameCXCL1
    Gene ID2919,574222
    Gene Symbol and SynonymsCXCL1,FSP,GRO1,GROa,MGSA,MGSA-a,NAP-3,SCYB1
    Uniprot AccessionP09341
    Uniprot Entry NameGROA_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseProstate Cancer, Malignant neoplasm of bladder
    Gene EnsemblENSG00000163739
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CXCL1, gene name: CXCL1, also named as FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.