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Anti-TWIST1 monoclonal antibody
Pre-made anti-TWIST1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TWIST1/TWIST1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T95660-Ab-1/ GM-Tg-hg-T95660-Ab-2 | Anti-Human TWIST1 monoclonal antibody | Human |
| GM-Tg-rg-T95660-Ab-1/ GM-Tg-rg-T95660-Ab-2 | Anti-Rat TWIST1 monoclonal antibody | Rat |
| GM-Tg-mg-T95660-Ab-1/ GM-Tg-mg-T95660-Ab-2 | Anti-Mouse TWIST1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T95660-Ab-1/ GM-Tg-cynog-T95660-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TWIST1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T95660-Ab-1/ GM-Tg-felg-T95660-Ab-2 | Anti-Feline TWIST1 monoclonal antibody | Feline |
| GM-Tg-cang-T95660-Ab-1/ GM-Tg-cang-T95660-Ab-2 | Anti-Canine TWIST1 monoclonal antibody | Canine |
| GM-Tg-bovg-T95660-Ab-1/ GM-Tg-bovg-T95660-Ab-2 | Anti-Bovine TWIST1 monoclonal antibody | Bovine |
| GM-Tg-equg-T95660-Ab-1/ GM-Tg-equg-T95660-Ab-2 | Anti-Equine TWIST1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T95660-Ab-1/ GM-Tg-hg-T95660-Ab-2; GM-Tg-rg-T95660-Ab-1/ GM-Tg-rg-T95660-Ab-2; GM-Tg-mg-T95660-Ab-1/ GM-Tg-mg-T95660-Ab-2; GM-Tg-cynog-T95660-Ab-1/ GM-Tg-cynog-T95660-Ab-2; GM-Tg-felg-T95660-Ab-1/ GM-Tg-felg-T95660-Ab-2; GM-Tg-cang-T95660-Ab-1/ GM-Tg-cang-T95660-Ab-2; GM-Tg-bovg-T95660-Ab-1/ GM-Tg-bovg-T95660-Ab-2; GM-Tg-equg-T95660-Ab-1/ GM-Tg-equg-T95660-Ab-2 |
| Products Name | Anti-TWIST1 monoclonal antibody |
| Format | mab |
| Target Name | TWIST1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TWIST1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T95660-Ag-1 | Recombinant multi-species TWST1/ TWIST1/ ACS3 protein |
| ORF Viral Vector | vGMAD000654 | human TWIST1 Adenovirus particle |
| ORF Viral Vector | vGMLV000590 | human TWIST1 Lentivirus particle |
| ORF Viral Vector | vGMLV000449 | human TWIST1 Lentivirus particle |
| ORF Viral Vector | pGMLV000590 | human TWIST1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000011 | human TWIST1 Adenovirus particle |
| ORF Viral Vector | pGMLV000449 | human TWIST1 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000011 | human TWIST1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000654 | human TWIST1 Adenovirus plasmid |
Target information
| Target ID | GM-T95660 |
| Target Name | TWIST1 |
| Gene ID | 7291,22160,85489,574278,119866614,101094007,782170,100272214 |
| Gene Symbol and Synonyms | ACS3,bHLHa38,BPES2,BPES3,CRS,CRS1,CSO,M-Twist,Pde,pdt,SCS,Ska10,Ska |
| Uniprot Accession | Q15672 |
| Uniprot Entry Name | TWST1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000122691 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: TWIST1, gene name: TWIST1, also named as ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, SWCOS, TWIST, bHLHa38. This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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