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Anti-LDLR/ LDL-R/ FH monoclonal antibody
Anti-LDLR/ LDL-R/ FH antibody for FACS & in-vivo assay
Go to LDL-R/LDLR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94692-Ab-1/ GM-Tg-hg-T94692-Ab-2 | Anti-Human LDL-R/LDLR monoclonal antibody | Human |
| GM-Tg-rg-T94692-Ab-1/ GM-Tg-rg-T94692-Ab-2 | Anti-Rat LDL-R/LDLR monoclonal antibody | Rat |
| GM-Tg-mg-T94692-Ab-1/ GM-Tg-mg-T94692-Ab-2 | Anti-Mouse LDL-R/LDLR monoclonal antibody | Mouse |
| GM-Tg-cynog-T94692-Ab-1/ GM-Tg-cynog-T94692-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LDL-R/LDLR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94692-Ab-1/ GM-Tg-felg-T94692-Ab-2 | Anti-Feline LDL-R/LDLR monoclonal antibody | Feline |
| GM-Tg-cang-T94692-Ab-1/ GM-Tg-cang-T94692-Ab-2 | Anti-Canine LDL-R/LDLR monoclonal antibody | Canine |
| GM-Tg-bovg-T94692-Ab-1/ GM-Tg-bovg-T94692-Ab-2 | Anti-Bovine LDL-R/LDLR monoclonal antibody | Bovine |
| GM-Tg-equg-T94692-Ab-1/ GM-Tg-equg-T94692-Ab-2 | Anti-Equine LDL-R/LDLR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94692-Ab-1/ GM-Tg-hg-T94692-Ab-2; GM-Tg-rg-T94692-Ab-1/ GM-Tg-rg-T94692-Ab-2; GM-Tg-mg-T94692-Ab-1/ GM-Tg-mg-T94692-Ab-2; GM-Tg-cynog-T94692-Ab-1/ GM-Tg-cynog-T94692-Ab-2; GM-Tg-felg-T94692-Ab-1/ GM-Tg-felg-T94692-Ab-2; GM-Tg-cang-T94692-Ab-1/ GM-Tg-cang-T94692-Ab-2; GM-Tg-bovg-T94692-Ab-1/ GM-Tg-bovg-T94692-Ab-2; GM-Tg-equg-T94692-Ab-1/ GM-Tg-equg-T94692-Ab-2 |
| Products Name | Anti-LDL-R/LDLR monoclonal antibody |
| Format | mab |
| Target Name | LDL-R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LDL-R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LDLR/ LDL-R/ FH VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP005154 | human LDLR Lentivirus particle |
| ORF Viral Vector | pGMLP005154 | human LDLR Lentivirus plasmid |
Target information
| Target ID | GM-T94692 |
| Target Name | LDL-R |
| Gene ID | 3949,16835,300438,574283,100683160,101080362,281276,100057389 |
| Gene Symbol and Synonyms | FH,FHC,FHCL1,Hlb301,LDLCQ2,LDLR,LDLRA |
| Uniprot Accession | P01130,P35952,P01131 |
| Uniprot Entry Name | LDLR_HUMAN,LDLR_RAT,LDLR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000130164 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LDL-R, gene name: LDLR, also named as FH, FHC, LDLCQ2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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