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Anti-CRLF1/ CISS/ CISS1 functional antibody
Anti-CRLF1/ CISS/ CISS1 functional antibody for cell culture, ELISA & in-vivo assay
Go to CRLF1/CRLF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94313-Ab-1/ GM-Tg-hg-T94313-Ab-2 | Anti-Human CRLF1 monoclonal antibody | Human |
| GM-Tg-rg-T94313-Ab-1/ GM-Tg-rg-T94313-Ab-2 | Anti-Rat CRLF1 monoclonal antibody | Rat |
| GM-Tg-mg-T94313-Ab-1/ GM-Tg-mg-T94313-Ab-2 | Anti-Mouse CRLF1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T94313-Ab-1/ GM-Tg-cynog-T94313-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRLF1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94313-Ab-1/ GM-Tg-felg-T94313-Ab-2 | Anti-Feline CRLF1 monoclonal antibody | Feline |
| GM-Tg-cang-T94313-Ab-1/ GM-Tg-cang-T94313-Ab-2 | Anti-Canine CRLF1 monoclonal antibody | Canine |
| GM-Tg-bovg-T94313-Ab-1/ GM-Tg-bovg-T94313-Ab-2 | Anti-Bovine CRLF1 monoclonal antibody | Bovine |
| GM-Tg-equg-T94313-Ab-1/ GM-Tg-equg-T94313-Ab-2 | Anti-Equine CRLF1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94313-Ab-1/ GM-Tg-hg-T94313-Ab-2; GM-Tg-rg-T94313-Ab-1/ GM-Tg-rg-T94313-Ab-2; GM-Tg-mg-T94313-Ab-1/ GM-Tg-mg-T94313-Ab-2; GM-Tg-cynog-T94313-Ab-1/ GM-Tg-cynog-T94313-Ab-2; GM-Tg-felg-T94313-Ab-1/ GM-Tg-felg-T94313-Ab-2; GM-Tg-cang-T94313-Ab-1/ GM-Tg-cang-T94313-Ab-2; GM-Tg-bovg-T94313-Ab-1/ GM-Tg-bovg-T94313-Ab-2; GM-Tg-equg-T94313-Ab-1/ GM-Tg-equg-T94313-Ab-2 |
| Products Name | Anti-CRLF1 monoclonal antibody |
| Format | mab |
| Target Name | CRLF1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRLF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T94313-Ag-1 | Recombinant multi-species CRLF1/ CISS/ CISS1 protein |
| Cytokine | GM-Tg-g-T94313-Ag-1 | cytokine receptor-like factor 1 (CRLF1) protein |
| ORF Viral Vector | pGMLP003678 | human CRLF1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003678 | human CRLF1 Lentivirus particle |
Target information
| Target ID | GM-T94313 |
| Target Name | CRLF1 |
| Gene ID | 9244,12931,290655,720247,484818,101095558,511086,100146959 |
| Gene Symbol and Synonyms | CISS,CISS1,CLF,CLF-1,CRLF1,CRLM-3,CRLM3,NR6,NR6.1,zcytor5 |
| Uniprot Accession | O75462 |
| Uniprot Entry Name | CRLF1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000006016 |
| Target Classification | N/A |
The target: CRLF1, gene name: CRLF1, also named as CISS, CISS1, CLF, CLF-1, NR6, zcytor5. This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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