Anti-CALC/ CALCA/ CALCA functional antibody

Anti-CALC/ CALCA/ CALCA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CALCA/CALCA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T93509-Ab-1/ GM-Tg-hg-T93509-Ab-2Anti-Human CALCA monoclonal antibodyHuman
GM-Tg-rg-T93509-Ab-1/ GM-Tg-rg-T93509-Ab-2Anti-Rat CALCA monoclonal antibodyRat
GM-Tg-mg-T93509-Ab-1/ GM-Tg-mg-T93509-Ab-2Anti-Mouse CALCA monoclonal antibodyMouse
GM-Tg-cynog-T93509-Ab-1/ GM-Tg-cynog-T93509-Ab-2Anti-Cynomolgus/ Rhesus macaque CALCA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T93509-Ab-1/ GM-Tg-felg-T93509-Ab-2Anti-Feline CALCA monoclonal antibodyFeline
GM-Tg-cang-T93509-Ab-1/ GM-Tg-cang-T93509-Ab-2Anti-Canine CALCA monoclonal antibodyCanine
GM-Tg-bovg-T93509-Ab-1/ GM-Tg-bovg-T93509-Ab-2Anti-Bovine CALCA monoclonal antibodyBovine
GM-Tg-equg-T93509-Ab-1/ GM-Tg-equg-T93509-Ab-2Anti-Equine CALCA monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T93509-Ab-1/ GM-Tg-hg-T93509-Ab-2; GM-Tg-rg-T93509-Ab-1/ GM-Tg-rg-T93509-Ab-2;
GM-Tg-mg-T93509-Ab-1/ GM-Tg-mg-T93509-Ab-2; GM-Tg-cynog-T93509-Ab-1/ GM-Tg-cynog-T93509-Ab-2;
GM-Tg-felg-T93509-Ab-1/ GM-Tg-felg-T93509-Ab-2; GM-Tg-cang-T93509-Ab-1/ GM-Tg-cang-T93509-Ab-2;
GM-Tg-bovg-T93509-Ab-1/ GM-Tg-bovg-T93509-Ab-2; GM-Tg-equg-T93509-Ab-1/ GM-Tg-equg-T93509-Ab-2
Products NameAnti-CALCA monoclonal antibody
Formatmab
Target NameCALCA
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CALCA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-228Pre-Made Galcanezumab biosimilar, Whole mAb, Anti-CALCA;CALCB Antibody: Anti-CT/KC/PCT/CGRP/CALC1/CGRP1/CGRP-I/CGRP-alpha;CALC2/CGRP-II/CGRP2 therapeutic antibody
    BiosimilarGMP-Bios-ab-191Pre-Made Eptinezumab biosimilar, Whole mAb, Anti-CALCA;CALCB Antibody: Anti-CT/KC/PCT/CGRP/CALC1/CGRP1/CGRP-I/CGRP-alpha;CALC2/CGRP-II/CGRP2 therapeutic antibody
    BiosimilarGMP-Bios-ab-222Pre-Made Fremanezumab biosimilar, Whole mAb, Anti-CALCA;CALCB Antibody: Anti-CT/KC/PCT/CGRP/CALC1/CGRP1/CGRP-I/CGRP-alpha;CALC2/CGRP-II/CGRP2 therapeutic antibody
    Target AntigenGM-Tg-g-T93509-Ag-1Recombinant multi-species CALC/ CALCA/ CALCA protein
    ORF Viral VectorpGMAP000285Human CALCA Adenovirus plasmid
    ORF Viral VectorpGMLP001920human CALCA Lentivirus plasmid
    ORF Viral VectorvGMLP001920human CALCA Lentivirus particle
    ORF Viral VectorvGMAP000285Human CALCA Adenovirus particle
    ORF Viral VectorpGMLPm000683mouse Calca Lentivirus plasmid
    ORF Viral VectorvGMLPm000683mouse Calca Lentivirus particle


    Target information

    Target IDGM-T93509
    Target NameCALCA
    Gene ID796,12310,24241,700649,403946,101095582
    Gene Symbol and SynonymsCA,Cal1,CAL6,Calc,CALC1,CALCA,calcitonin,CCALCI,CGRP,CGRP-1,CGRP-alpha,CGRP-I,CGRP1,CT,Ctn,KC,PCT,RATCAL6
    Uniprot AccessionP01258, P06881,P01256,P01257,P41547,Q9MYV1
    Uniprot Entry NameCALCA_HUMAN,CALCA_RAT,CALC_RAT,CALC_CANLF,CALCA_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker, INN Index
    DiseaseHead and Neck Cancer
    Gene EnsemblENSG00000110680
    Target ClassificationN/A

    The target: CALCA, gene name: CALCA, also named as CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.