Anti-PSN1/ PSEN1/ ACNINV3 monoclonal antibody

Anti-PSN1/ PSEN1/ ACNINV3 antibody for FACS & in-vivo assay

Target products collectionGo to PSEN1/PSEN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T93105-Ab-1/ GM-Tg-hg-T93105-Ab-2Anti-Human PSEN1 monoclonal antibodyHuman
GM-Tg-rg-T93105-Ab-1/ GM-Tg-rg-T93105-Ab-2Anti-Rat PSEN1 monoclonal antibodyRat
GM-Tg-mg-T93105-Ab-1/ GM-Tg-mg-T93105-Ab-2Anti-Mouse PSEN1 monoclonal antibodyMouse
GM-Tg-cynog-T93105-Ab-1/ GM-Tg-cynog-T93105-Ab-2Anti-Cynomolgus/ Rhesus macaque PSEN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T93105-Ab-1/ GM-Tg-felg-T93105-Ab-2Anti-Feline PSEN1 monoclonal antibodyFeline
GM-Tg-cang-T93105-Ab-1/ GM-Tg-cang-T93105-Ab-2Anti-Canine PSEN1 monoclonal antibodyCanine
GM-Tg-bovg-T93105-Ab-1/ GM-Tg-bovg-T93105-Ab-2Anti-Bovine PSEN1 monoclonal antibodyBovine
GM-Tg-equg-T93105-Ab-1/ GM-Tg-equg-T93105-Ab-2Anti-Equine PSEN1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T93105-Ab-1/ GM-Tg-hg-T93105-Ab-2; GM-Tg-rg-T93105-Ab-1/ GM-Tg-rg-T93105-Ab-2;
GM-Tg-mg-T93105-Ab-1/ GM-Tg-mg-T93105-Ab-2; GM-Tg-cynog-T93105-Ab-1/ GM-Tg-cynog-T93105-Ab-2;
GM-Tg-felg-T93105-Ab-1/ GM-Tg-felg-T93105-Ab-2; GM-Tg-cang-T93105-Ab-1/ GM-Tg-cang-T93105-Ab-2;
GM-Tg-bovg-T93105-Ab-1/ GM-Tg-bovg-T93105-Ab-2; GM-Tg-equg-T93105-Ab-1/ GM-Tg-equg-T93105-Ab-2
Products NameAnti-PSEN1 monoclonal antibody
Formatmab
Target NamePSEN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PSEN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PSN1/ PSEN1/ ACNINV3 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000462human PSEN1 Lentivirus plasmid
    ORF Viral VectorpGMLV000766human PSEN1 Lentivirus plasmid
    ORF Viral VectorvGMLV000462human PSEN1 Lentivirus particle
    ORF Viral VectorvGMLV000766human PSEN1 Lentivirus particle


    Target information

    Target IDGM-T93105
    Target NamePSEN1
    Gene ID5663,19164,29192,696274,403408,101087239,282705,100050164
    Gene Symbol and SynonymsACNINV3,AD3,Ad3h,FAD,PS-1,PS1,PSEN1,PSNL1,S182
    Uniprot AccessionP49768,P97887,Q6RH31,Q9XT97
    Uniprot Entry NamePSN1_HUMAN,PSN1_RAT,PSN1_CANLF,PSN1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000080815
    Target ClassificationN/A

    The target: PSEN1, gene name: PSEN1, also named as ACNINV3, AD3, FAD, PS-1, PS1, S182. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.