Anti-AREG/ ARB/ CRDGF functional antibody

Anti-AREG/ ARB/ CRDGF functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to AREG/AREG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T92834-Ab-1/ GM-Tg-hg-T92834-Ab-2Anti-Human AREG monoclonal antibodyHuman
GM-Tg-rg-T92834-Ab-1/ GM-Tg-rg-T92834-Ab-2Anti-Rat AREG monoclonal antibodyRat
GM-Tg-mg-T92834-Ab-1/ GM-Tg-mg-T92834-Ab-2Anti-Mouse AREG monoclonal antibodyMouse
GM-Tg-cynog-T92834-Ab-1/ GM-Tg-cynog-T92834-Ab-2Anti-Cynomolgus/ Rhesus macaque AREG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T92834-Ab-1/ GM-Tg-felg-T92834-Ab-2Anti-Feline AREG monoclonal antibodyFeline
GM-Tg-cang-T92834-Ab-1/ GM-Tg-cang-T92834-Ab-2Anti-Canine AREG monoclonal antibodyCanine
GM-Tg-bovg-T92834-Ab-1/ GM-Tg-bovg-T92834-Ab-2Anti-Bovine AREG monoclonal antibodyBovine
GM-Tg-equg-T92834-Ab-1/ GM-Tg-equg-T92834-Ab-2Anti-Equine AREG monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T92834-Ab-1/ GM-Tg-hg-T92834-Ab-2; GM-Tg-rg-T92834-Ab-1/ GM-Tg-rg-T92834-Ab-2;
GM-Tg-mg-T92834-Ab-1/ GM-Tg-mg-T92834-Ab-2; GM-Tg-cynog-T92834-Ab-1/ GM-Tg-cynog-T92834-Ab-2;
GM-Tg-felg-T92834-Ab-1/ GM-Tg-felg-T92834-Ab-2; GM-Tg-cang-T92834-Ab-1/ GM-Tg-cang-T92834-Ab-2;
GM-Tg-bovg-T92834-Ab-1/ GM-Tg-bovg-T92834-Ab-2; GM-Tg-equg-T92834-Ab-1/ GM-Tg-equg-T92834-Ab-2
Products NameAnti-AREG monoclonal antibody
Formatmab
Target NameAREG
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AREG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T92834-Ag-1Recombinant multi-species AREG/ ARB/ CRDGF protein
    CytokineGM-Tg-g-T92834-Ag-1amphiregulin (AREG) protein
    ORF Viral VectorpGMAP000225Human AREG Adenovirus plasmid
    ORF Viral VectorpGMLP000520human AREG Lentivirus plasmid
    ORF Viral VectorvGMLP000520human AREG Lentivirus particle
    ORF Viral VectorvGMAP000225Human AREG Adenovirus particle
    ORF Viral VectorpGMLV000735house mouse Areg Lentivirus plasmid
    ORF Viral VectorpGMLPm000610mouse Areg Lentivirus plasmid
    ORF Viral VectorvGMLV000735house mouse Areg Lentivirus particle
    ORF Viral VectorvGMLPm000610mouse Areg Lentivirus particle


    Target information

    Target IDGM-T92834
    Target NameAREG
    Gene ID374,11839,29183,702396,475176,101081041,538751,100050528
    Gene Symbol and SynonymsAR,AREG,AREGB,CRDGF,Mcub,SDGF
    Uniprot AccessionP15514,P24338
    Uniprot Entry NameAREG_HUMAN,AREG_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000109321
    Target ClassificationTumor-associated antigen (TAA)

    The target: AREG, gene name: AREG, also named as ARB, CRDGF, SDGF, AREG. The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.