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Anti-ADA1A/ ADRA1A/ ADRA1C monoclonal antibody
Anti-ADA1A/ ADRA1A/ ADRA1C antibody for FACS & in-vivo assay
Go to ADRA1A/ADRA1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92609-Ab-1/ GM-Tg-hg-T92609-Ab-2 | Anti-Human ADRA1A monoclonal antibody | Human |
| GM-Tg-rg-T92609-Ab-1/ GM-Tg-rg-T92609-Ab-2 | Anti-Rat ADRA1A monoclonal antibody | Rat |
| GM-Tg-mg-T92609-Ab-1/ GM-Tg-mg-T92609-Ab-2 | Anti-Mouse ADRA1A monoclonal antibody | Mouse |
| GM-Tg-cynog-T92609-Ab-1/ GM-Tg-cynog-T92609-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRA1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92609-Ab-1/ GM-Tg-felg-T92609-Ab-2 | Anti-Feline ADRA1A monoclonal antibody | Feline |
| GM-Tg-cang-T92609-Ab-1/ GM-Tg-cang-T92609-Ab-2 | Anti-Canine ADRA1A monoclonal antibody | Canine |
| GM-Tg-bovg-T92609-Ab-1/ GM-Tg-bovg-T92609-Ab-2 | Anti-Bovine ADRA1A monoclonal antibody | Bovine |
| GM-Tg-equg-T92609-Ab-1/ GM-Tg-equg-T92609-Ab-2 | Anti-Equine ADRA1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92609-Ab-1/ GM-Tg-hg-T92609-Ab-2; GM-Tg-rg-T92609-Ab-1/ GM-Tg-rg-T92609-Ab-2; GM-Tg-mg-T92609-Ab-1/ GM-Tg-mg-T92609-Ab-2; GM-Tg-cynog-T92609-Ab-1/ GM-Tg-cynog-T92609-Ab-2; GM-Tg-felg-T92609-Ab-1/ GM-Tg-felg-T92609-Ab-2; GM-Tg-cang-T92609-Ab-1/ GM-Tg-cang-T92609-Ab-2; GM-Tg-bovg-T92609-Ab-1/ GM-Tg-bovg-T92609-Ab-2; GM-Tg-equg-T92609-Ab-1/ GM-Tg-equg-T92609-Ab-2 |
| Products Name | Anti-ADRA1A monoclonal antibody |
| Format | mab |
| Target Name | ADRA1A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADRA1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ADA1A/ ADRA1A/ ADRA1C VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003225 | human ADRA1A Lentivirus particle |
| ORF Viral Vector | pGMLP003225 | human ADRA1A Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005141 | mouse Adra1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005141 | mouse Adra1a Lentivirus particle |
Target information
| Target ID | GM-T92609 |
| Target Name | ADRA1A |
| Gene ID | 148,11549,29412,712509,403866,101098375,282134,100054461 |
| Gene Symbol and Synonyms | ADRA1A,ADRA1C,ADRA1L1,ALPHA-1A,ALPHA1AAR |
| Uniprot Accession | P35348,P43140,O77621,P18130 |
| Uniprot Entry Name | ADA1A_HUMAN,ADA1A_RAT,ADA1A_CANLF,ADA1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000120907 |
| Target Classification | GPCR |
The target: ADRA1A, gene name: ADRA1A, also named as ADRA1C, ADRA1L1, ALPHA1AAR. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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