Anti-PACR/ PAC1R/ ADCYAP1R1 monoclonal antibody

Anti-PACR/ PAC1R/ ADCYAP1R1 antibody for FACS & in-vivo assay

Target products collectionGo to PAC1R/ADCYAP1R1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T92185-Ab-1/ GM-Tg-hg-T92185-Ab-2Anti-Human PAC1R/ADCYAP1R1 monoclonal antibodyHuman
GM-Tg-rg-T92185-Ab-1/ GM-Tg-rg-T92185-Ab-2Anti-Rat PAC1R/ADCYAP1R1 monoclonal antibodyRat
GM-Tg-mg-T92185-Ab-1/ GM-Tg-mg-T92185-Ab-2Anti-Mouse PAC1R/ADCYAP1R1 monoclonal antibodyMouse
GM-Tg-cynog-T92185-Ab-1/ GM-Tg-cynog-T92185-Ab-2Anti-Cynomolgus/ Rhesus macaque PAC1R/ADCYAP1R1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T92185-Ab-1/ GM-Tg-felg-T92185-Ab-2Anti-Feline PAC1R/ADCYAP1R1 monoclonal antibodyFeline
GM-Tg-cang-T92185-Ab-1/ GM-Tg-cang-T92185-Ab-2Anti-Canine PAC1R/ADCYAP1R1 monoclonal antibodyCanine
GM-Tg-bovg-T92185-Ab-1/ GM-Tg-bovg-T92185-Ab-2Anti-Bovine PAC1R/ADCYAP1R1 monoclonal antibodyBovine
GM-Tg-equg-T92185-Ab-1/ GM-Tg-equg-T92185-Ab-2Anti-Equine PAC1R/ADCYAP1R1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T92185-Ab-1/ GM-Tg-hg-T92185-Ab-2; GM-Tg-rg-T92185-Ab-1/ GM-Tg-rg-T92185-Ab-2;
GM-Tg-mg-T92185-Ab-1/ GM-Tg-mg-T92185-Ab-2; GM-Tg-cynog-T92185-Ab-1/ GM-Tg-cynog-T92185-Ab-2;
GM-Tg-felg-T92185-Ab-1/ GM-Tg-felg-T92185-Ab-2; GM-Tg-cang-T92185-Ab-1/ GM-Tg-cang-T92185-Ab-2;
GM-Tg-bovg-T92185-Ab-1/ GM-Tg-bovg-T92185-Ab-2; GM-Tg-equg-T92185-Ab-1/ GM-Tg-equg-T92185-Ab-2
Products NameAnti-PAC1R/ADCYAP1R1 monoclonal antibody
Formatmab
Target NamePAC1R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PAC1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-643Pre-Made Zelminemab biosimilar, Whole mAb, Anti-ADCYAP1R1/PAC1R Antibody: Anti-PAC1/PACAPR/PACAPRI therapeutic antibody
    Target AntigenProducts DevelopingMulti-species PACR/ PAC1R/ ADCYAP1R1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm002115mouse Adcyap1r1 Lentivirus plasmid
    ORF Viral VectorpGMLPm002116mouse Adcyap1r1 Lentivirus plasmid
    ORF Viral VectorvGMLPm002115mouse Adcyap1r1 Lentivirus particle
    ORF Viral VectorvGMLPm002116mouse Adcyap1r1 Lentivirus particle


    Target information

    Target IDGM-T92185
    Target NamePAC1R
    Gene ID117,11517,24167,695483,482386,101088396,319095,100069948
    Gene Symbol and Synonyms2900024I10Rik,ADCYAP1R1,PAC1,PAC1-R,PAC1R,PACAP-R1,PACAP-R1A,PACAP1-R,PACAPR,PACAPR1,PACAPR1A,PACAPRI
    Uniprot AccessionP41586,P32215,Q29627
    Uniprot Entry NamePACR_HUMAN,PACR_RAT,PACR_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000078549
    Target ClassificationGPCR

    The target: PAC1R, gene name: ADCYAP1R1, also named as PAC1, PAC1R, PACAPR, PACAPRI. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.