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Anti-DPYL2/ DPYSL2/ CRMP-2 monoclonal antibody
Anti-DPYL2/ DPYSL2/ CRMP-2 antibody for FACS & in-vivo assay
Go to DPYSL2/DPYSL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92078-Ab-1/ GM-Tg-hg-T92078-Ab-2 | Anti-Human DPYSL2 monoclonal antibody | Human |
| GM-Tg-rg-T92078-Ab-1/ GM-Tg-rg-T92078-Ab-2 | Anti-Rat DPYSL2 monoclonal antibody | Rat |
| GM-Tg-mg-T92078-Ab-1/ GM-Tg-mg-T92078-Ab-2 | Anti-Mouse DPYSL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92078-Ab-1/ GM-Tg-cynog-T92078-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DPYSL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92078-Ab-1/ GM-Tg-felg-T92078-Ab-2 | Anti-Feline DPYSL2 monoclonal antibody | Feline |
| GM-Tg-cang-T92078-Ab-1/ GM-Tg-cang-T92078-Ab-2 | Anti-Canine DPYSL2 monoclonal antibody | Canine |
| GM-Tg-bovg-T92078-Ab-1/ GM-Tg-bovg-T92078-Ab-2 | Anti-Bovine DPYSL2 monoclonal antibody | Bovine |
| GM-Tg-equg-T92078-Ab-1/ GM-Tg-equg-T92078-Ab-2 | Anti-Equine DPYSL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92078-Ab-1/ GM-Tg-hg-T92078-Ab-2; GM-Tg-rg-T92078-Ab-1/ GM-Tg-rg-T92078-Ab-2; GM-Tg-mg-T92078-Ab-1/ GM-Tg-mg-T92078-Ab-2; GM-Tg-cynog-T92078-Ab-1/ GM-Tg-cynog-T92078-Ab-2; GM-Tg-felg-T92078-Ab-1/ GM-Tg-felg-T92078-Ab-2; GM-Tg-cang-T92078-Ab-1/ GM-Tg-cang-T92078-Ab-2; GM-Tg-bovg-T92078-Ab-1/ GM-Tg-bovg-T92078-Ab-2; GM-Tg-equg-T92078-Ab-1/ GM-Tg-equg-T92078-Ab-2 |
| Products Name | Anti-DPYSL2 monoclonal antibody |
| Format | mab |
| Target Name | DPYSL2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DPYSL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DPYL2/ DPYSL2/ CRMP-2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002679 | mouse Dpysl2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002679 | mouse Dpysl2 Lentivirus particle |
Target information
| Target ID | GM-T92078 |
| Target Name | DPYSL2 |
| Gene ID | 1808,12934,25416,712368,486107,554340,533746,100054410 |
| Gene Symbol and Synonyms | CRMP-2,CRMP2,DHPRP2,DPYSL2,DRP-2,DRP2,Musunc33,N2A3,TOAD-64,ULIP-2,ULIP2 |
| Uniprot Accession | Q16555,P47942,O02675 |
| Uniprot Entry Name | DPYL2_HUMAN,DPYL2_RAT,DPYL2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000092964 |
| Target Classification | N/A |
The target: DPYSL2, gene name: DPYSL2, also named as CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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