- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CASR/ CAR/ EIG8 monoclonal antibody
Anti-CASR/ CAR/ EIG8 antibody for FACS & in-vivo assay
Go to CASR/CASR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92076-Ab-1/ GM-Tg-hg-T92076-Ab-2 | Anti-Human CASR monoclonal antibody | Human |
| GM-Tg-rg-T92076-Ab-1/ GM-Tg-rg-T92076-Ab-2 | Anti-Rat CASR monoclonal antibody | Rat |
| GM-Tg-mg-T92076-Ab-1/ GM-Tg-mg-T92076-Ab-2 | Anti-Mouse CASR monoclonal antibody | Mouse |
| GM-Tg-cynog-T92076-Ab-1/ GM-Tg-cynog-T92076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CASR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92076-Ab-1/ GM-Tg-felg-T92076-Ab-2 | Anti-Feline CASR monoclonal antibody | Feline |
| GM-Tg-cang-T92076-Ab-1/ GM-Tg-cang-T92076-Ab-2 | Anti-Canine CASR monoclonal antibody | Canine |
| GM-Tg-bovg-T92076-Ab-1/ GM-Tg-bovg-T92076-Ab-2 | Anti-Bovine CASR monoclonal antibody | Bovine |
| GM-Tg-equg-T92076-Ab-1/ GM-Tg-equg-T92076-Ab-2 | Anti-Equine CASR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92076-Ab-1/ GM-Tg-hg-T92076-Ab-2; GM-Tg-rg-T92076-Ab-1/ GM-Tg-rg-T92076-Ab-2; GM-Tg-mg-T92076-Ab-1/ GM-Tg-mg-T92076-Ab-2; GM-Tg-cynog-T92076-Ab-1/ GM-Tg-cynog-T92076-Ab-2; GM-Tg-felg-T92076-Ab-1/ GM-Tg-felg-T92076-Ab-2; GM-Tg-cang-T92076-Ab-1/ GM-Tg-cang-T92076-Ab-2; GM-Tg-bovg-T92076-Ab-1/ GM-Tg-bovg-T92076-Ab-2; GM-Tg-equg-T92076-Ab-1/ GM-Tg-equg-T92076-Ab-2 |
| Products Name | Anti-CASR monoclonal antibody |
| Format | mab |
| Target Name | CASR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CASR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CASR/ CAR/ EIG8 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000369 | human CASR Lentivirus plasmid |
| ORF Viral Vector | vGMLV000369 | human CASR Lentivirus particle |
Target information
| Target ID | GM-T92076 |
| Target Name | CASR |
| Gene ID | 846,12374,24247,714441,488007,100302732,281038,100034084 |
| Gene Symbol and Synonyms | BoPCaR1,CAR,CASR,EIG8,FHH,FIH,GPRC2A,hCasR,HHC,HHC1,HYPOC1,NSHPT,PCAR1,RaKCaR |
| Uniprot Accession | P41180,P48442,P35384 |
| Uniprot Entry Name | CASR_HUMAN,CASR_RAT,CASR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000036828 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CASR, gene name: CASR, also named as CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR. The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
