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Anti-ROR2/ BDB/ BDB1 monoclonal antibody
Anti-ROR2/ BDB/ BDB1 antibody for FACS & in-vivo assay
Go to ROR2/ROR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T91435-Ab-1/ GM-Tg-hg-T91435-Ab-2 | Anti-Human ROR2 monoclonal antibody | Human |
| GM-Tg-rg-T91435-Ab-1/ GM-Tg-rg-T91435-Ab-2 | Anti-Rat ROR2 monoclonal antibody | Rat |
| GM-Tg-mg-T91435-Ab-1/ GM-Tg-mg-T91435-Ab-2 | Anti-Mouse ROR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T91435-Ab-1/ GM-Tg-cynog-T91435-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ROR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T91435-Ab-1/ GM-Tg-felg-T91435-Ab-2 | Anti-Feline ROR2 monoclonal antibody | Feline |
| GM-Tg-cang-T91435-Ab-1/ GM-Tg-cang-T91435-Ab-2 | Anti-Canine ROR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T91435-Ab-1/ GM-Tg-bovg-T91435-Ab-2 | Anti-Bovine ROR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T91435-Ab-1/ GM-Tg-equg-T91435-Ab-2 | Anti-Equine ROR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T91435-Ab-1/ GM-Tg-hg-T91435-Ab-2; GM-Tg-rg-T91435-Ab-1/ GM-Tg-rg-T91435-Ab-2; GM-Tg-mg-T91435-Ab-1/ GM-Tg-mg-T91435-Ab-2; GM-Tg-cynog-T91435-Ab-1/ GM-Tg-cynog-T91435-Ab-2; GM-Tg-felg-T91435-Ab-1/ GM-Tg-felg-T91435-Ab-2; GM-Tg-cang-T91435-Ab-1/ GM-Tg-cang-T91435-Ab-2; GM-Tg-bovg-T91435-Ab-1/ GM-Tg-bovg-T91435-Ab-2; GM-Tg-equg-T91435-Ab-1/ GM-Tg-equg-T91435-Ab-2 |
| Products Name | Anti-ROR2 monoclonal antibody |
| Format | mab |
| Target Name | ROR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ROR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ROR2/ BDB/ BDB1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000584 | human ROR2 Adenovirus particle |
| ORF Viral Vector | pGMAD000584 | human ROR2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004465 | mouse Ror2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004465 | mouse Ror2 Lentivirus particle |
Target information
| Target ID | GM-T91435 |
| Target Name | ROR2 |
| Gene ID | 4920,26564,306782,715482,484193,101087689,785924,100064718 |
| Gene Symbol and Synonyms | BDB,BDB1,NTRKR2,ROR2 |
| Uniprot Accession | Q01974 |
| Uniprot Entry Name | ROR2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000169071 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: ROR2, gene name: ROR2, also named as BDB, BDB1, NTRKR2. The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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