Anti-FGFR4/ CD334/ JTK2 monoclonal antibody

Anti-FGFR4/ CD334/ JTK2 antibody for FACS & in-vivo assay

Target products collectionGo to FGFR4/FGFR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T90989-Ab-1/ GM-Tg-hg-T90989-Ab-2Anti-Human FGFR4 monoclonal antibodyHuman
GM-Tg-rg-T90989-Ab-1/ GM-Tg-rg-T90989-Ab-2Anti-Rat FGFR4 monoclonal antibodyRat
GM-Tg-mg-T90989-Ab-1/ GM-Tg-mg-T90989-Ab-2Anti-Mouse FGFR4 monoclonal antibodyMouse
GM-Tg-cynog-T90989-Ab-1/ GM-Tg-cynog-T90989-Ab-2Anti-Cynomolgus/ Rhesus macaque FGFR4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T90989-Ab-1/ GM-Tg-felg-T90989-Ab-2Anti-Feline FGFR4 monoclonal antibodyFeline
GM-Tg-cang-T90989-Ab-1/ GM-Tg-cang-T90989-Ab-2Anti-Canine FGFR4 monoclonal antibodyCanine
GM-Tg-bovg-T90989-Ab-1/ GM-Tg-bovg-T90989-Ab-2Anti-Bovine FGFR4 monoclonal antibodyBovine
GM-Tg-equg-T90989-Ab-1/ GM-Tg-equg-T90989-Ab-2Anti-Equine FGFR4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T90989-Ab-1/ GM-Tg-hg-T90989-Ab-2; GM-Tg-rg-T90989-Ab-1/ GM-Tg-rg-T90989-Ab-2;
GM-Tg-mg-T90989-Ab-1/ GM-Tg-mg-T90989-Ab-2; GM-Tg-cynog-T90989-Ab-1/ GM-Tg-cynog-T90989-Ab-2;
GM-Tg-felg-T90989-Ab-1/ GM-Tg-felg-T90989-Ab-2; GM-Tg-cang-T90989-Ab-1/ GM-Tg-cang-T90989-Ab-2;
GM-Tg-bovg-T90989-Ab-1/ GM-Tg-bovg-T90989-Ab-2; GM-Tg-equg-T90989-Ab-1/ GM-Tg-equg-T90989-Ab-2
Products NameAnti-FGFR4 monoclonal antibody
Formatmab
Target NameFGFR4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FGFR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-727Pre-Made Aldafermin Biosimilar, Recombinant Protein targeting FGFR4: Recombinant therapeutic protein targeting CD334/JTK2/TKF
    Target AntigenProducts DevelopingMulti-species FGFR4/ CD334/ JTK2 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T90989-Ag-1Fibroblast growth factor receptor 4 (FGFR4) protein
    ORF Viral VectorvGMLV000558human FGFR4 Lentivirus particle
    ORF Viral VectorpGMLV000558human FGFR4 Lentivirus plasmid


    Target information

    Target IDGM-T90989
    Target NameFGFR4
    Gene ID2264,14186,25114,698494,489095,101100864,317696,100068679
    Gene Symbol and SynonymsCD334,Fgfr-4,FGFR4,JTK2,TKF
    Uniprot AccessionP22455,Q498D6
    Uniprot Entry NameFGFR4_HUMAN,FGFR4_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseBreast Cancer, Ovary Cancer
    Gene EnsemblENSG00000160867
    Target ClassificationKinase

    The target: FGFR4, gene name: FGFR4, also named as CD334, JTK2, TKF. The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.