Anti-IGF2/ C11orf43/ GRDF functional antibody

Anti-IGF2/ C11orf43/ GRDF functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IGF2/IGF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T90572-Ab-1/ GM-Tg-hg-T90572-Ab-2Anti-Human IGF2 monoclonal antibodyHuman
GM-Tg-rg-T90572-Ab-1/ GM-Tg-rg-T90572-Ab-2Anti-Rat IGF2 monoclonal antibodyRat
GM-Tg-mg-T90572-Ab-1/ GM-Tg-mg-T90572-Ab-2Anti-Mouse IGF2 monoclonal antibodyMouse
GM-Tg-cynog-T90572-Ab-1/ GM-Tg-cynog-T90572-Ab-2Anti-Cynomolgus/ Rhesus macaque IGF2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T90572-Ab-1/ GM-Tg-felg-T90572-Ab-2Anti-Feline IGF2 monoclonal antibodyFeline
GM-Tg-cang-T90572-Ab-1/ GM-Tg-cang-T90572-Ab-2Anti-Canine IGF2 monoclonal antibodyCanine
GM-Tg-bovg-T90572-Ab-1/ GM-Tg-bovg-T90572-Ab-2Anti-Bovine IGF2 monoclonal antibodyBovine
GM-Tg-equg-T90572-Ab-1/ GM-Tg-equg-T90572-Ab-2Anti-Equine IGF2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T90572-Ab-1/ GM-Tg-hg-T90572-Ab-2; GM-Tg-rg-T90572-Ab-1/ GM-Tg-rg-T90572-Ab-2;
GM-Tg-mg-T90572-Ab-1/ GM-Tg-mg-T90572-Ab-2; GM-Tg-cynog-T90572-Ab-1/ GM-Tg-cynog-T90572-Ab-2;
GM-Tg-felg-T90572-Ab-1/ GM-Tg-felg-T90572-Ab-2; GM-Tg-cang-T90572-Ab-1/ GM-Tg-cang-T90572-Ab-2;
GM-Tg-bovg-T90572-Ab-1/ GM-Tg-bovg-T90572-Ab-2; GM-Tg-equg-T90572-Ab-1/ GM-Tg-equg-T90572-Ab-2
Products NameAnti-IGF2 monoclonal antibody
Formatmab
Target NameIGF2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IGF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-634Pre-Made Xentuzumab biosimilar, Whole mAb, Anti-IGF1;IGF2 Antibody: Anti-IGF/IGF-I/IGFI/MGF;C11orf43/GRDF/IGF-II/PP9974/SRS3 therapeutic antibody
    BiosimilarGMP-Bios-ab-160Pre-Made Dusigitumab biosimilar, Whole mAb, Anti-IGF1;IGF2 Antibody: Anti-IGF/IGF-I/IGFI/MGF;C11orf43/GRDF/IGF-II/PP9974/SRS3 therapeutic antibody
    Target AntigenGM-Tg-g-T90572-Ag-1Recombinant multi-species IGF2/ C11orf43/ GRDF protein
    CytokineGM-Tg-g-T90572-Ag-1insulin-like growth factor 2 (IGF2) protein
    ORF Viral VectorvGMLV000393human IGF2 Lentivirus particle
    ORF Viral VectorpGMLV000475human IGF2 Lentivirus plasmid
    ORF Viral VectorpGMLV000393human IGF2 Lentivirus plasmid
    ORF Viral VectorpGMAP000466Human IGF2 Adenovirus plasmid
    ORF Viral VectorvGMLV000475human IGF2 Lentivirus particle
    ORF Viral VectorvGMAP000466Human IGF2 Adenovirus particle
    ORF Viral VectorpGMLV000050rat Igf2 Lentivirus plasmid
    ORF Viral VectorpGMAD000117mouse Igf2 Adenovirus plasmid
    ORF Viral VectorpGMAAV000051mouse Igf2 AAV plasmid
    ORF Viral VectorpGMAAV000327house mouse Igf2 AAV plasmid
    ORF Viral VectorvGMLV000050rat Igf2 Lentivirus particle
    ORF Viral VectorvGMAD000117mouse Igf2 Adenovirus particle
    ORF Viral VectorvGMAAV000051mouse Igf2 AAV particle
    ORF Viral VectorvGMAAV000327house mouse Igf2 AAV particle


    Target information

    Target IDGM-T90572
    Target NameIGF2
    Gene ID3481,16002,24483,710802,483664,101093644,281240,100034182
    Gene Symbol and SynonymsC11orf43,GRDF,Igf-2,IGF-II,IGF2,IGFII,M6pr,Mpr,Peg2,PP9974,RNIGF2,SRS3
    Uniprot AccessionP01344,P01346,P07456,P51459
    Uniprot Entry NameIGF2_HUMAN,IGF2_RAT,IGF2_BOVIN,IGF2_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000167244
    Target ClassificationN/A

    The target: IGF2, gene name: IGF2, also named as C11orf43, GRDF, IGF-II, PP9974. This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.