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Anti-DTL monoclonal antibody
Pre-made anti-DTL monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DTL/DTL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T89521-Ab-1/ GM-Tg-hg-T89521-Ab-2 | Anti-Human DTL monoclonal antibody | Human |
| GM-Tg-rg-T89521-Ab-1/ GM-Tg-rg-T89521-Ab-2 | Anti-Rat DTL monoclonal antibody | Rat |
| GM-Tg-mg-T89521-Ab-1/ GM-Tg-mg-T89521-Ab-2 | Anti-Mouse DTL monoclonal antibody | Mouse |
| GM-Tg-cynog-T89521-Ab-1/ GM-Tg-cynog-T89521-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DTL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T89521-Ab-1/ GM-Tg-felg-T89521-Ab-2 | Anti-Feline DTL monoclonal antibody | Feline |
| GM-Tg-cang-T89521-Ab-1/ GM-Tg-cang-T89521-Ab-2 | Anti-Canine DTL monoclonal antibody | Canine |
| GM-Tg-bovg-T89521-Ab-1/ GM-Tg-bovg-T89521-Ab-2 | Anti-Bovine DTL monoclonal antibody | Bovine |
| GM-Tg-equg-T89521-Ab-1/ GM-Tg-equg-T89521-Ab-2 | Anti-Equine DTL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T89521-Ab-1/ GM-Tg-hg-T89521-Ab-2; GM-Tg-rg-T89521-Ab-1/ GM-Tg-rg-T89521-Ab-2; GM-Tg-mg-T89521-Ab-1/ GM-Tg-mg-T89521-Ab-2; GM-Tg-cynog-T89521-Ab-1/ GM-Tg-cynog-T89521-Ab-2; GM-Tg-felg-T89521-Ab-1/ GM-Tg-felg-T89521-Ab-2; GM-Tg-cang-T89521-Ab-1/ GM-Tg-cang-T89521-Ab-2; GM-Tg-bovg-T89521-Ab-1/ GM-Tg-bovg-T89521-Ab-2; GM-Tg-equg-T89521-Ab-1/ GM-Tg-equg-T89521-Ab-2 |
| Products Name | Anti-DTL monoclonal antibody |
| Format | mab |
| Target Name | DTL |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DTL monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T89521-Ag-1 | Recombinant multi-species DTL/ CDT2/ DCAF2 protein |
| ORF Viral Vector | vGMLV000109 | human DTL Lentivirus particle |
| ORF Viral Vector | pGMLV000109 | human DTL Lentivirus plasmid |
| ORF Viral Vector | vGMLV000110 | human DTL Lentivirus particle |
| ORF Viral Vector | vGMLV000531 | human DTL Lentivirus particle |
| ORF Viral Vector | pGMLV000531 | human DTL Lentivirus plasmid |
| ORF Viral Vector | pGMLV000110 | human DTL Lentivirus plasmid |
Target information
| Target ID | GM-T89521 |
| Target Name | DTL |
| Gene ID | 51514,76843,305073,711236,490279,101100689,539953,100054533 |
| Gene Symbol and Synonyms | 2810047L02Rik,5730564G15Rik,CDT2,DCAF2,DTL,L2DTL,RAMP,RGD1310439 |
| Uniprot Accession | Q9NZJ0 |
| Uniprot Entry Name | DTL_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000143476 |
| Target Classification | N/A |
The target: DTL, gene name: DTL, also named as CDT2, DCAF2, L2DTL, RAMP. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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