Anti-NF2L2/ Nrf2/ NFE2L2 monoclonal antibody

Anti-NF2L2/ Nrf2/ NFE2L2 antibody for FACS & in-vivo assay

Target products collectionGo to Nrf2/NFE2L2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T88505-Ab-1/ GM-Tg-hg-T88505-Ab-2Anti-Human Nrf2/NFE2L2 monoclonal antibodyHuman
GM-Tg-rg-T88505-Ab-1/ GM-Tg-rg-T88505-Ab-2Anti-Rat Nrf2/NFE2L2 monoclonal antibodyRat
GM-Tg-mg-T88505-Ab-1/ GM-Tg-mg-T88505-Ab-2Anti-Mouse Nrf2/NFE2L2 monoclonal antibodyMouse
GM-Tg-cynog-T88505-Ab-1/ GM-Tg-cynog-T88505-Ab-2Anti-Cynomolgus/ Rhesus macaque Nrf2/NFE2L2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T88505-Ab-1/ GM-Tg-felg-T88505-Ab-2Anti-Feline Nrf2/NFE2L2 monoclonal antibodyFeline
GM-Tg-cang-T88505-Ab-1/ GM-Tg-cang-T88505-Ab-2Anti-Canine Nrf2/NFE2L2 monoclonal antibodyCanine
GM-Tg-bovg-T88505-Ab-1/ GM-Tg-bovg-T88505-Ab-2Anti-Bovine Nrf2/NFE2L2 monoclonal antibodyBovine
GM-Tg-equg-T88505-Ab-1/ GM-Tg-equg-T88505-Ab-2Anti-Equine Nrf2/NFE2L2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T88505-Ab-1/ GM-Tg-hg-T88505-Ab-2; GM-Tg-rg-T88505-Ab-1/ GM-Tg-rg-T88505-Ab-2;
GM-Tg-mg-T88505-Ab-1/ GM-Tg-mg-T88505-Ab-2; GM-Tg-cynog-T88505-Ab-1/ GM-Tg-cynog-T88505-Ab-2;
GM-Tg-felg-T88505-Ab-1/ GM-Tg-felg-T88505-Ab-2; GM-Tg-cang-T88505-Ab-1/ GM-Tg-cang-T88505-Ab-2;
GM-Tg-bovg-T88505-Ab-1/ GM-Tg-bovg-T88505-Ab-2; GM-Tg-equg-T88505-Ab-1/ GM-Tg-equg-T88505-Ab-2
Products NameAnti-Nrf2/NFE2L2 monoclonal antibody
Formatmab
Target NameNrf2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-Nrf2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NF2L2/ Nrf2/ NFE2L2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000194human NFE2L2 Lentivirus particle
    ORF Viral VectorvGMLV000643human NFE2L2 Lentivirus particle
    ORF Viral VectorpGMLV000569human nrf2 Lentivirus plasmid
    ORF Viral VectorpGMLV000194human NFE2L2 Lentivirus plasmid
    ORF Viral VectorvGMLV000569human nrf2 Lentivirus particle
    ORF Viral VectorpGMLV000643human NFE2L2 Lentivirus plasmid
    ORF Viral VectorvGMLV000762human NFE2L2 Lentivirus particle
    ORF Viral VectorpGMLV000762human NFE2L2 Lentivirus plasmid
    ORF Viral VectorpGMLV000784house mouse Nfe2l2 Lentivirus plasmid
    ORF Viral VectorpGMAAV000087rat Nfe2l2 AAV plasmid
    ORF Viral VectorvGMLV000784house mouse Nfe2l2 Lentivirus particle
    ORF Viral VectorvGMAAV000087rat Nfe2l2 AAV particle


    Target information

    Target IDGM-T88505
    Target NameNrf2
    Gene ID4780,18024,83619,707606,478813,101098812,497024,100066816
    Gene Symbol and SynonymsHEBP1,IMDDHH,NFE2L2,Nrf-2,NRF2
    Uniprot AccessionQ16236,O54968,Q5NUA6
    Uniprot Entry NameNF2L2_HUMAN,NF2L2_RAT,NF2L2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000116044
    Target ClassificationPathway, Tumor-associated antigen (TAA)

    The target: Nrf2, gene name: NFE2L2, also named as HEBP1, IMDDHH, NRF2. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.