Anti-TNR8/ TNFRSF8/ CD30 monoclonal antibody

Anti-TNR8/ TNFRSF8/ CD30 antibody for FACS & in-vivo assay

Target products collectionGo to TNFRSF8/TNFRSF8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T88023-Ab-1/ GM-Tg-hg-T88023-Ab-2Anti-Human TNFRSF8 monoclonal antibodyHuman
GM-Tg-rg-T88023-Ab-1/ GM-Tg-rg-T88023-Ab-2Anti-Rat TNFRSF8 monoclonal antibodyRat
GM-Tg-mg-T88023-Ab-1/ GM-Tg-mg-T88023-Ab-2Anti-Mouse TNFRSF8 monoclonal antibodyMouse
GM-Tg-cynog-T88023-Ab-1/ GM-Tg-cynog-T88023-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFRSF8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T88023-Ab-1/ GM-Tg-felg-T88023-Ab-2Anti-Feline TNFRSF8 monoclonal antibodyFeline
GM-Tg-cang-T88023-Ab-1/ GM-Tg-cang-T88023-Ab-2Anti-Canine TNFRSF8 monoclonal antibodyCanine
GM-Tg-bovg-T88023-Ab-1/ GM-Tg-bovg-T88023-Ab-2Anti-Bovine TNFRSF8 monoclonal antibodyBovine
GM-Tg-equg-T88023-Ab-1/ GM-Tg-equg-T88023-Ab-2Anti-Equine TNFRSF8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T88023-Ab-1/ GM-Tg-hg-T88023-Ab-2; GM-Tg-rg-T88023-Ab-1/ GM-Tg-rg-T88023-Ab-2;
GM-Tg-mg-T88023-Ab-1/ GM-Tg-mg-T88023-Ab-2; GM-Tg-cynog-T88023-Ab-1/ GM-Tg-cynog-T88023-Ab-2;
GM-Tg-felg-T88023-Ab-1/ GM-Tg-felg-T88023-Ab-2; GM-Tg-cang-T88023-Ab-1/ GM-Tg-cang-T88023-Ab-2;
GM-Tg-bovg-T88023-Ab-1/ GM-Tg-bovg-T88023-Ab-2; GM-Tg-equg-T88023-Ab-1/ GM-Tg-equg-T88023-Ab-2
Products NameAnti-TNFRSF8 monoclonal antibody
Formatmab
Target NameTNFRSF8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFRSF8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-765Pre-Made Brentuximab Vedotin Biosimilar, Whole Mab Adc, Anti-Tnfrsf8 Antibody: Anti-CD30/D1S166E/Ki-1 therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-080Pre-Made Brentuximab biosimilar, Whole mAb ADC, Anti-TNFRSF8 Antibody: Anti-CD30/Ki-1/D1S166E therapeutic antibody
    BiosimilarGMP-Bios-ab-278Pre-Made Iratumumab biosimilar, Whole mAb, Anti-TNFRSF8 Antibody: Anti-CD30/Ki-1/D1S166E therapeutic antibody
    Target AntigenProducts DevelopingMulti-species TNR8/ TNFRSF8/ CD30 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T88023-Ag-1tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) protein
    ORF Viral VectorpGMLPm004985mouse Tnfrsf8 Lentivirus plasmid
    ORF Viral VectorvGMLPm004985mouse Tnfrsf8 Lentivirus particle


    Target information

    Target IDGM-T88023
    Target NameTNFRSF8
    Gene ID943,21941,25069,722773,487438,101101575,614780,100055885
    Gene Symbol and SynonymsCD30,D1S166E,Ki,Ki-1,TNFRSF8
    Uniprot AccessionP28908,P97525
    Uniprot Entry NameTNR8_HUMAN,TNR8_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000120949
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: TNFRSF8, gene name: TNFRSF8, also named as CD30, D1S166E, Ki-1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.