Anti-ROR1/ NTRKR1/ dJ537F10.1 monoclonal antibody

Anti-ROR1/ NTRKR1/ dJ537F10.1 antibody for FACS & in-vivo assay

Target products collectionGo to ROR1/ROR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T87871-Ab-1/ GM-Tg-hg-T87871-Ab-2Anti-Human ROR1 monoclonal antibodyHuman
GM-Tg-rg-T87871-Ab-1/ GM-Tg-rg-T87871-Ab-2Anti-Rat ROR1 monoclonal antibodyRat
GM-Tg-mg-T87871-Ab-1/ GM-Tg-mg-T87871-Ab-2Anti-Mouse ROR1 monoclonal antibodyMouse
GM-Tg-cynog-T87871-Ab-1/ GM-Tg-cynog-T87871-Ab-2Anti-Cynomolgus/ Rhesus macaque ROR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T87871-Ab-1/ GM-Tg-felg-T87871-Ab-2Anti-Feline ROR1 monoclonal antibodyFeline
GM-Tg-cang-T87871-Ab-1/ GM-Tg-cang-T87871-Ab-2Anti-Canine ROR1 monoclonal antibodyCanine
GM-Tg-bovg-T87871-Ab-1/ GM-Tg-bovg-T87871-Ab-2Anti-Bovine ROR1 monoclonal antibodyBovine
GM-Tg-equg-T87871-Ab-1/ GM-Tg-equg-T87871-Ab-2Anti-Equine ROR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T87871-Ab-1/ GM-Tg-hg-T87871-Ab-2; GM-Tg-rg-T87871-Ab-1/ GM-Tg-rg-T87871-Ab-2;
GM-Tg-mg-T87871-Ab-1/ GM-Tg-mg-T87871-Ab-2; GM-Tg-cynog-T87871-Ab-1/ GM-Tg-cynog-T87871-Ab-2;
GM-Tg-felg-T87871-Ab-1/ GM-Tg-felg-T87871-Ab-2; GM-Tg-cang-T87871-Ab-1/ GM-Tg-cang-T87871-Ab-2;
GM-Tg-bovg-T87871-Ab-1/ GM-Tg-bovg-T87871-Ab-2; GM-Tg-equg-T87871-Ab-1/ GM-Tg-equg-T87871-Ab-2
Products NameAnti-ROR1 monoclonal antibody
Formatmab
Target NameROR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ROR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-647Pre-Made Zilovertamab biosimilar, Whle mAb, Anti-ROR1 Antibody: Anti-NTRKR1/dJ537F10.1 therapeutic antibody
    BiosimilarGMP-Bios-INN-1057Pre-Made Zilovertamab Vedotin Biosimilar, Whole Mab Adc, Anti-Ror1 Antibody: Anti-NTRKR1/dJ537F10.1 therapeutic antibody Drug Conjugate
    Target AntigenProducts DevelopingMulti-species ROR1/ NTRKR1/ dJ537F10.1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000229human ROR1 Lentivirus particle
    ORF Viral VectorpGMAD000585human ROR1 Adenovirus plasmid
    ORF Viral VectorvGMAD000585human ROR1 Adenovirus particle
    ORF Viral VectorpGMLV000229human ROR1 Lentivirus plasmid


    Target information

    Target IDGM-T87871
    Target NameROR1
    Gene ID4919,26563,362550,700760,489557,101100987,783965,100069962
    Gene Symbol and Synonyms2810404D04Rik,dJ537F10.1,NTRKR1,RGD1559469,ROR1
    Uniprot AccessionQ01973
    Uniprot Entry NameROR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000185483
    Target ClassificationCheckpoint-Immuno Oncology

    The target: ROR1, gene name: ROR1, also named as NTRKR1, dJ537F10.1. This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.