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Anti-PDGFB/ IBGC5/ PDGF-2 functional antibody
Anti-PDGFB/ IBGC5/ PDGF-2 functional antibody for cell culture, ELISA & in-vivo assay
Go to PDGFB/PDGFB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T87350-Ab-1/ GM-Tg-hg-T87350-Ab-2 | Anti-Human PDGFB monoclonal antibody | Human |
| GM-Tg-rg-T87350-Ab-1/ GM-Tg-rg-T87350-Ab-2 | Anti-Rat PDGFB monoclonal antibody | Rat |
| GM-Tg-mg-T87350-Ab-1/ GM-Tg-mg-T87350-Ab-2 | Anti-Mouse PDGFB monoclonal antibody | Mouse |
| GM-Tg-cynog-T87350-Ab-1/ GM-Tg-cynog-T87350-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDGFB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T87350-Ab-1/ GM-Tg-felg-T87350-Ab-2 | Anti-Feline PDGFB monoclonal antibody | Feline |
| GM-Tg-cang-T87350-Ab-1/ GM-Tg-cang-T87350-Ab-2 | Anti-Canine PDGFB monoclonal antibody | Canine |
| GM-Tg-bovg-T87350-Ab-1/ GM-Tg-bovg-T87350-Ab-2 | Anti-Bovine PDGFB monoclonal antibody | Bovine |
| GM-Tg-equg-T87350-Ab-1/ GM-Tg-equg-T87350-Ab-2 | Anti-Equine PDGFB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T87350-Ab-1/ GM-Tg-hg-T87350-Ab-2; GM-Tg-rg-T87350-Ab-1/ GM-Tg-rg-T87350-Ab-2; GM-Tg-mg-T87350-Ab-1/ GM-Tg-mg-T87350-Ab-2; GM-Tg-cynog-T87350-Ab-1/ GM-Tg-cynog-T87350-Ab-2; GM-Tg-felg-T87350-Ab-1/ GM-Tg-felg-T87350-Ab-2; GM-Tg-cang-T87350-Ab-1/ GM-Tg-cang-T87350-Ab-2; GM-Tg-bovg-T87350-Ab-1/ GM-Tg-bovg-T87350-Ab-2; GM-Tg-equg-T87350-Ab-1/ GM-Tg-equg-T87350-Ab-2 |
| Products Name | Anti-PDGFB monoclonal antibody |
| Format | mab |
| Target Name | PDGFB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDGFB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T87350-Ag-1 | Recombinant multi-species PDGFB/ IBGC5/ PDGF-2 protein |
| Cytokine | GM-Tg-g-T87350-Ag-1 | platelet derived growth factor subunit B (PDGFB) protein |
| ORF Viral Vector | vGMAP000122 | Human PDGFB Adenovirus particle |
| ORF Viral Vector | pGMAP000122 | Human PDGFB Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001029 | mouse Pdgfb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001029 | mouse Pdgfb Lentivirus particle |
Target information
| Target ID | GM-T87350 |
| Target Name | PDGFB |
| Gene ID | 5155,18591,24628,703173,442986,100135774,540106,100070283 |
| Gene Symbol and Synonyms | c-sis,cis,IBGC5,PDGF,PDGF-2,PDGF-B,PDGF2,PDGFB,SIS,SSV |
| Uniprot Accession | P01127,Q05028,Q6Q7I7,P12919 |
| Uniprot Entry Name | PDGFB_HUMAN,PDGFB_RAT,PDGFB_FELCA,PDGFB_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Chronic Kidney Disease |
| Gene Ensembl | ENSG00000100311 |
| Target Classification | N/A |
The target: PDGFB, gene name: PDGFB, also named as IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis. This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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