Anti-TNR11/ ODFR/ TNFRSF11A monoclonal antibody

Anti-TNR11/ ODFR/ TNFRSF11A antibody for FACS & in-vivo assay

Target products collectionGo to ODFR/TNFRSF11A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T85746-Ab-1/ GM-Tg-hg-T85746-Ab-2Anti-Human ODFR/TNFRSF11A monoclonal antibodyHuman
GM-Tg-rg-T85746-Ab-1/ GM-Tg-rg-T85746-Ab-2Anti-Rat ODFR/TNFRSF11A monoclonal antibodyRat
GM-Tg-mg-T85746-Ab-1/ GM-Tg-mg-T85746-Ab-2Anti-Mouse ODFR/TNFRSF11A monoclonal antibodyMouse
GM-Tg-cynog-T85746-Ab-1/ GM-Tg-cynog-T85746-Ab-2Anti-Cynomolgus/ Rhesus macaque ODFR/TNFRSF11A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T85746-Ab-1/ GM-Tg-felg-T85746-Ab-2Anti-Feline ODFR/TNFRSF11A monoclonal antibodyFeline
GM-Tg-cang-T85746-Ab-1/ GM-Tg-cang-T85746-Ab-2Anti-Canine ODFR/TNFRSF11A monoclonal antibodyCanine
GM-Tg-bovg-T85746-Ab-1/ GM-Tg-bovg-T85746-Ab-2Anti-Bovine ODFR/TNFRSF11A monoclonal antibodyBovine
GM-Tg-equg-T85746-Ab-1/ GM-Tg-equg-T85746-Ab-2Anti-Equine ODFR/TNFRSF11A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T85746-Ab-1/ GM-Tg-hg-T85746-Ab-2; GM-Tg-rg-T85746-Ab-1/ GM-Tg-rg-T85746-Ab-2;
GM-Tg-mg-T85746-Ab-1/ GM-Tg-mg-T85746-Ab-2; GM-Tg-cynog-T85746-Ab-1/ GM-Tg-cynog-T85746-Ab-2;
GM-Tg-felg-T85746-Ab-1/ GM-Tg-felg-T85746-Ab-2; GM-Tg-cang-T85746-Ab-1/ GM-Tg-cang-T85746-Ab-2;
GM-Tg-bovg-T85746-Ab-1/ GM-Tg-bovg-T85746-Ab-2; GM-Tg-equg-T85746-Ab-1/ GM-Tg-equg-T85746-Ab-2
Products NameAnti-ODFR/TNFRSF11A monoclonal antibody
Formatmab
Target NameODFR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ODFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TNR11/ ODFR/ TNFRSF11A VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T85746-Ag-1tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A) protein
    ORF Viral VectorpGMLP001749human TNFRSF11A Lentivirus plasmid
    ORF Viral VectorvGMLP001749human TNFRSF11A Lentivirus particle


    Target information

    Target IDGM-T85746
    Target NameODFR
    Gene ID8792,21934,498206,100424175,483957,101090651,530884,100056617
    Gene Symbol and SynonymsCD265,FEO,LOH18CR1,Ly109,mRANK,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,RGD1563614,TNFRSF11A,TRANCE-R,TRANCER
    Uniprot AccessionQ9Y6Q6
    Uniprot Entry NameTNR11_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000141655
    Target ClassificationCheckpoint-Immuno Oncology, Pathway, Tumor-associated antigen (TAA)

    The target: ODFR, gene name: TNFRSF11A, also named as CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.