Anti-NGF/ Beta-NGF/ HSAN5B functional antibody

Anti-NGF/ Beta-NGF/ HSAN5B functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NGF/NGF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T85670-Ab-1/ GM-Tg-hg-T85670-Ab-2Anti-Human NGF monoclonal antibodyHuman
GM-Tg-rg-T85670-Ab-1/ GM-Tg-rg-T85670-Ab-2Anti-Rat NGF monoclonal antibodyRat
GM-Tg-mg-T85670-Ab-1/ GM-Tg-mg-T85670-Ab-2Anti-Mouse NGF monoclonal antibodyMouse
GM-Tg-cynog-T85670-Ab-1/ GM-Tg-cynog-T85670-Ab-2Anti-Cynomolgus/ Rhesus macaque NGF monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T85670-Ab-1/ GM-Tg-felg-T85670-Ab-2Anti-Feline NGF monoclonal antibodyFeline
GM-Tg-cang-T85670-Ab-1/ GM-Tg-cang-T85670-Ab-2Anti-Canine NGF monoclonal antibodyCanine
GM-Tg-bovg-T85670-Ab-1/ GM-Tg-bovg-T85670-Ab-2Anti-Bovine NGF monoclonal antibodyBovine
GM-Tg-equg-T85670-Ab-1/ GM-Tg-equg-T85670-Ab-2Anti-Equine NGF monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T85670-Ab-1/ GM-Tg-hg-T85670-Ab-2; GM-Tg-rg-T85670-Ab-1/ GM-Tg-rg-T85670-Ab-2;
GM-Tg-mg-T85670-Ab-1/ GM-Tg-mg-T85670-Ab-2; GM-Tg-cynog-T85670-Ab-1/ GM-Tg-cynog-T85670-Ab-2;
GM-Tg-felg-T85670-Ab-1/ GM-Tg-felg-T85670-Ab-2; GM-Tg-cang-T85670-Ab-1/ GM-Tg-cang-T85670-Ab-2;
GM-Tg-bovg-T85670-Ab-1/ GM-Tg-bovg-T85670-Ab-2; GM-Tg-equg-T85670-Ab-1/ GM-Tg-equg-T85670-Ab-2
Products NameAnti-NGF monoclonal antibody
Formatmab
Target NameNGF
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NGF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T85670-Ag-1Recombinant multi-species NGF/ Beta-NGF/ HSAN5B protein
    CytokineGM-Tg-g-T85670-Ag-1Nerve growth factor (NGF) protein
    ORF Viral VectorvGMLV000284human NGF Lentivirus particle
    ORF Viral VectorpGMLV000284human NGF Lentivirus plasmid
    ORF Viral VectorpGMAAV000148rat Ngf AAV plasmid
    ORF Viral VectorpGMAAV000279house mouse Ngf AAV plasmid
    ORF Viral VectorpGMLPm000818mouse Ngf Lentivirus plasmid
    ORF Viral VectorvGMAAV000148rat Ngf AAV particle
    ORF Viral VectorvGMAAV000279house mouse Ngf AAV particle
    ORF Viral VectorvGMLPm000818mouse Ngf Lentivirus particle


    Target information

    Target IDGM-T85670
    Target NameNGF
    Gene ID4803,18049,310738,711681,403402,100144611,281350,100065669
    Gene Symbol and SynonymsBeta-NGF,HSAN5,NGF,NGFB
    Uniprot AccessionP01138,P25427,P13600
    Uniprot Entry NameNGF_HUMAN,NGF_RAT,NGF_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseOveractive bladder, Bladder Pain, Interstitial cystitis (chronic), Urinary Tract Infection, Neurological deficits - peripheral neuropathy, Parkinson's Disease
    Gene EnsemblENSG00000134259
    Target ClassificationN/A

    The target: NGF, gene name: NGF, also named as Beta-NGF, HSAN5B, NGF. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.