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Anti-KDM5C monoclonal antibody
Pre-made anti-KDM5C monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KDM5C/KDM5C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85540-Ab-1/ GM-Tg-hg-T85540-Ab-2 | Anti-Human KDM5C monoclonal antibody | Human |
| GM-Tg-rg-T85540-Ab-1/ GM-Tg-rg-T85540-Ab-2 | Anti-Rat KDM5C monoclonal antibody | Rat |
| GM-Tg-mg-T85540-Ab-1/ GM-Tg-mg-T85540-Ab-2 | Anti-Mouse KDM5C monoclonal antibody | Mouse |
| GM-Tg-cynog-T85540-Ab-1/ GM-Tg-cynog-T85540-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KDM5C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85540-Ab-1/ GM-Tg-felg-T85540-Ab-2 | Anti-Feline KDM5C monoclonal antibody | Feline |
| GM-Tg-cang-T85540-Ab-1/ GM-Tg-cang-T85540-Ab-2 | Anti-Canine KDM5C monoclonal antibody | Canine |
| GM-Tg-bovg-T85540-Ab-1/ GM-Tg-bovg-T85540-Ab-2 | Anti-Bovine KDM5C monoclonal antibody | Bovine |
| GM-Tg-equg-T85540-Ab-1/ GM-Tg-equg-T85540-Ab-2 | Anti-Equine KDM5C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85540-Ab-1/ GM-Tg-hg-T85540-Ab-2; GM-Tg-rg-T85540-Ab-1/ GM-Tg-rg-T85540-Ab-2; GM-Tg-mg-T85540-Ab-1/ GM-Tg-mg-T85540-Ab-2; GM-Tg-cynog-T85540-Ab-1/ GM-Tg-cynog-T85540-Ab-2; GM-Tg-felg-T85540-Ab-1/ GM-Tg-felg-T85540-Ab-2; GM-Tg-cang-T85540-Ab-1/ GM-Tg-cang-T85540-Ab-2; GM-Tg-bovg-T85540-Ab-1/ GM-Tg-bovg-T85540-Ab-2; GM-Tg-equg-T85540-Ab-1/ GM-Tg-equg-T85540-Ab-2 |
| Products Name | Anti-KDM5C monoclonal antibody |
| Format | mab |
| Target Name | KDM5C |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KDM5C monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T85540-Ag-1 | Recombinant multi-species KDM5C/ DXS1272E/ JARID1C protein |
| ORF Viral Vector | pGMAD000260 | mouse Kdm5c Adenovirus plasmid |
| ORF Viral Vector | vGMAD000260 | mouse Kdm5c Adenovirus particle |
Target information
| Target ID | GM-T85540 |
| Target Name | KDM5C |
| Gene ID | 8242,20591,317432,106992262,491894,101091600,281490,100034190 |
| Gene Symbol and Synonyms | D930009K15Rik,DXS1272E,JARID1C,KDM5C,mKIAA0234,MRX13,MRXJ,MRXSCJ,MRXSJ,RGD1560601,SMCX,XE169 |
| Uniprot Accession | P41229,Q38JA7 |
| Uniprot Entry Name | KDM5C_HUMAN,KDM5C_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000126012 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: KDM5C, gene name: KDM5C, also named as DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169. This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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