Anti-INSR/ CD220/ HHF5 monoclonal antibody

Anti-INSR/ CD220/ HHF5 antibody for FACS & in-vivo assay

Target products collectionGo to INSR/INSR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T85435-Ab-1/ GM-Tg-hg-T85435-Ab-2Anti-Human INSR monoclonal antibodyHuman
GM-Tg-rg-T85435-Ab-1/ GM-Tg-rg-T85435-Ab-2Anti-Rat INSR monoclonal antibodyRat
GM-Tg-mg-T85435-Ab-1/ GM-Tg-mg-T85435-Ab-2Anti-Mouse INSR monoclonal antibodyMouse
GM-Tg-cynog-T85435-Ab-1/ GM-Tg-cynog-T85435-Ab-2Anti-Cynomolgus/ Rhesus macaque INSR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T85435-Ab-1/ GM-Tg-felg-T85435-Ab-2Anti-Feline INSR monoclonal antibodyFeline
GM-Tg-cang-T85435-Ab-1/ GM-Tg-cang-T85435-Ab-2Anti-Canine INSR monoclonal antibodyCanine
GM-Tg-bovg-T85435-Ab-1/ GM-Tg-bovg-T85435-Ab-2Anti-Bovine INSR monoclonal antibodyBovine
GM-Tg-equg-T85435-Ab-1/ GM-Tg-equg-T85435-Ab-2Anti-Equine INSR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T85435-Ab-1/ GM-Tg-hg-T85435-Ab-2; GM-Tg-rg-T85435-Ab-1/ GM-Tg-rg-T85435-Ab-2;
GM-Tg-mg-T85435-Ab-1/ GM-Tg-mg-T85435-Ab-2; GM-Tg-cynog-T85435-Ab-1/ GM-Tg-cynog-T85435-Ab-2;
GM-Tg-felg-T85435-Ab-1/ GM-Tg-felg-T85435-Ab-2; GM-Tg-cang-T85435-Ab-1/ GM-Tg-cang-T85435-Ab-2;
GM-Tg-bovg-T85435-Ab-1/ GM-Tg-bovg-T85435-Ab-2; GM-Tg-equg-T85435-Ab-1/ GM-Tg-equg-T85435-Ab-2
Products NameAnti-INSR monoclonal antibody
Formatmab
Target NameINSR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-INSR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-870Pre-Made Insulin Efsitora Alfa Biosimilar, Fusion Protein targeting INSR fused with human IGHG2 Fc (Fragment constant): Recombinant therapeutic protein targeting CD220/HHF5
    BiosimilarGMP-Bios-INN-1043Pre-Made Valanafusp Alfa Biosimilar, Fusion Protein targeting INSR fused with human IDUA (iduronidase, alpha-L-) (1:2): Recombinant therapeutic protein targeting CD220/HHF5
    BiosimilarGMP-Bios-INN-869Pre-Made Insulin Biosimilar, Recombinant Protein targeting INSR: Recombinant therapeutic protein targeting CD220/HHF5
    BiosimilarGMP-Bios-ab-608Pre-Made Valanafusp biosimilar, Whole mAb Fusion, Anti-INSR Antibody: Anti-CD220/HHF5 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species INSR/ CD220/ HHF5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T85435
    Target NameINSR
    Gene ID3643,16337,24954,706009,484990,100127108,408017,100066248
    Gene Symbol and Synonyms4932439J01Rik,CD220,D630014A15Rik,HHF5,INSR,IR,IR-A,IR-B
    Uniprot AccessionP06213,P15127,Q28516
    Uniprot Entry NameINSR_HUMAN,INSR_MACMU,INSR_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseIgA glomerulonephritis
    Gene EnsemblENSG00000171105
    Target ClassificationKinase

    The target: INSR, gene name: INSR, also named as CD220, HHF5. This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.