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Anti-CCR7/ BLR2/ CC-CKR-7 monoclonal antibody
Anti-CCR7/ BLR2/ CC-CKR-7 antibody for FACS & in-vivo assay
Go to CCR7/CCR7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T84981-Ab-1/ GM-Tg-hg-T84981-Ab-2 | Anti-Human CCR7 monoclonal antibody | Human |
| GM-Tg-rg-T84981-Ab-1/ GM-Tg-rg-T84981-Ab-2 | Anti-Rat CCR7 monoclonal antibody | Rat |
| GM-Tg-mg-T84981-Ab-1/ GM-Tg-mg-T84981-Ab-2 | Anti-Mouse CCR7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T84981-Ab-1/ GM-Tg-cynog-T84981-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T84981-Ab-1/ GM-Tg-felg-T84981-Ab-2 | Anti-Feline CCR7 monoclonal antibody | Feline |
| GM-Tg-cang-T84981-Ab-1/ GM-Tg-cang-T84981-Ab-2 | Anti-Canine CCR7 monoclonal antibody | Canine |
| GM-Tg-bovg-T84981-Ab-1/ GM-Tg-bovg-T84981-Ab-2 | Anti-Bovine CCR7 monoclonal antibody | Bovine |
| GM-Tg-equg-T84981-Ab-1/ GM-Tg-equg-T84981-Ab-2 | Anti-Equine CCR7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T84981-Ab-1/ GM-Tg-hg-T84981-Ab-2; GM-Tg-rg-T84981-Ab-1/ GM-Tg-rg-T84981-Ab-2; GM-Tg-mg-T84981-Ab-1/ GM-Tg-mg-T84981-Ab-2; GM-Tg-cynog-T84981-Ab-1/ GM-Tg-cynog-T84981-Ab-2; GM-Tg-felg-T84981-Ab-1/ GM-Tg-felg-T84981-Ab-2; GM-Tg-cang-T84981-Ab-1/ GM-Tg-cang-T84981-Ab-2; GM-Tg-bovg-T84981-Ab-1/ GM-Tg-bovg-T84981-Ab-2; GM-Tg-equg-T84981-Ab-1/ GM-Tg-equg-T84981-Ab-2 |
| Products Name | Anti-CCR7 monoclonal antibody |
| Format | mab |
| Target Name | CCR7 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR7/ BLR2/ CC-CKR-7 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T84981-Ag-1 | chemokine (C-C motif) receptor 7 (CCR7) protein |
| ORF Viral Vector | pGMLP003944 | human CCR7 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003944 | human CCR7 Lentivirus particle |
| ORF Viral Vector | pGMAD000405 | rat Ccr7 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002790 | mouse Ccr7 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000405 | rat Ccr7 Adenovirus particle |
| ORF Viral Vector | vGMLPm002790 | mouse Ccr7 Lentivirus particle |
Target information
| Target ID | GM-T84981 |
| Target Name | CCR7 |
| Gene ID | 1236,12775,287673,574231,491011,101084327,510668,100067673 |
| Gene Symbol and Synonyms | BLR2,CC-CKR-7,CCR-7,CCR7,CD197,CDw197,CMKBR7,EBI1,Ebi1h |
| Uniprot Accession | P32248,Q5MD62 |
| Uniprot Entry Name | CCR7_HUMAN,CCR7_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000126353 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: CCR7, gene name: CCR7, also named as BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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